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Diss Factsheets
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EC number: 609-724-7 | CAS number: 39605-45-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Jun 1990 - Dec 1990
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- 1981
- Deviations:
- yes
- Remarks:
- Temperature higher than norm (23°C) noted each afternoon during the 3 days of the study: max. 27°C. Humidity lower than norm (30 %): min. 18 % R.H. These deviations were not considered to have affected the outcome or the objectives of the study.
- Qualifier:
- according to guideline
- Guideline:
- EPA OTS 798.4470 (Acute Dermal Irritation)
- Version / remarks:
- 1985
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Terbuthylazine
- EC Number:
- 227-637-9
- EC Name:
- Terbuthylazine
- Cas Number:
- 5915-41-3
- Molecular formula:
- C9H16ClN5
- IUPAC Name:
- N-tert-butyl-6-chloro-N'-ethyl-1,3,5-triazine-2,4-diamine
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Appearance: white powder
- Storage condition of test material: room temperature in the dark
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Bancel, Albon, France
- Age at study initiation: adult
- Weight at study initiation: 2.45 - 2.55 kg
- Housing: single
- Diet: approx. 150 g per animal per day
- Water: ad libitum
- Acclimation period: 12 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21-27
- Humidity (%): 18-54
- Air changes (per hr): not specified
- Photoperiod (hrs dark / hrs light): 12/12 (illumination: 7.30 am to 7.30 pm)
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- water
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0.5 g (0.6 ml)
- Concentration: 0.5 g (i.e. 1.8693 g of purified water for 4 g of test article)
VEHICLE
- Concentration: 0.23 g purified water
- Duration of treatment / exposure:
- 4 h
- Observation period:
- 1, 24, 48, 72 h
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: back or flank
- Coverage: approx. 6 cm²
- Type of wrap if used: 8-layer thick Codex hydrophilic gauze
REMOVAL OF TEST SUBSTANCE
- Washing: yes, surplus test article was removed using a gauze compress moistened with purified water
- Time after start of exposure: 4 h
OBSERVATION TIME POINTS
- 1, 24, 48, 72 h
SCORING SYSTEM:
- Method of calculation: Calculation of the mean values for primary cutaneous irritation from the evaluation of the erythematous and oedematous lesions observed at 24, 48 and 72 hours (and possibly at Days 7 and l4) according to a given numerical scale
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Other effects:
- - Other adverse systemic effects: no mortality, no changes in behavior, no clinical signs
Any other information on results incl. tables
Evaluation of irritation after removal of semi-occlusive patches
RABBITS N° |
58143 |
58146 |
58147 |
58148 |
58153 |
58160 |
TOTAL |
MEAN |
|
|
1 H |
1 |
1 |
0 |
0 |
0 |
0 |
2 |
0.33 |
24 H |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0.00 |
|
48 H |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0.00 |
|
72 H |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0.00 |
|
|
ERYTHEMA: MEAN 24 H + 48 H + 72 H |
0.00 |
RABBITS N° |
58143 |
58146 |
58147 |
58148 |
58153 |
58160 |
TOTAL |
MEAN |
|
|
1 HOUR |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0.00 |
24 HOURS |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0.00 |
|
48 HOURS |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0.00 |
|
72 HOURS |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0.00 |
|
|
OEDEMA: MEAN 24 H+48 H+72H |
0.00 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the consitions of the study, the test substance did not cause skin irritation in rabbits and thus was concluded not to be an irritant.
- Executive summary:
The test article was applied at the dose level of 0.5 g prepared as a paste with 0.23 g of purified water, per animal, under a semi-occlusive patch for 4 hours, to the intact skin of 6 New-Zealand hybrid albino male rabbits. The cutaneous examinations were performed, for erythema and oedema, according to a given numerical scale, 1, 24, 48 and 72 hours after removal of the patch. Mean values were calculated from the evaluation of the cutaneous lesions performed in all the rabbits examined at 24, 48 and 72 hours. Mean values for cutaneous irritation were as follows :
- at 24 hours : 0.00; 0.00 (erythema and oedema)
- at 48 hours : 0.00; 0.00 (erythema and oedema)
- at 72 hours : 0.00; 0.00 (erythema and oedema)
i.e. a global average (24 hours + 48 hours + 72 hours) of 0.00 for erythema and of 0.00 for oedema. In conclusion, from the results obtained under the experimental conditions, application of this test article to the rabbit' skin can be designated as non-irritant.
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