Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-638-2 | CAS number: 123-62-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions (no GLP)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Principles of method if other than guideline:
- The study was conducted according to an internal BASF method which was in principle comparable to the OECD guideline 401. A test group consisting of 5 animals/sex/dose was treated by single gavage with an aqueous solution of the test substance. The animals were weighed prior treatment only. The animals were observed for mortality and for clinical signs of toxicity for a period of 14 days. Decedents were subjected to necropsy. At the end of the observation period, the surviving animals were sacrificed (CO2 aphyxiation) for the purpose of necropsy. The LD50 value was estimated on the basis of the observed mortalities using the Lichtfield and Wilcoxon method
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Propionic acid
- EC Number:
- 201-176-3
- EC Name:
- Propionic acid
- Cas Number:
- 79-09-4
- Molecular formula:
- C3H6O2
- IUPAC Name:
- propanoic acid
- Details on test material:
- Analytical purity: > 99%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Firma Gassner/Ottobrunn
- Age at study initiation: no data
- Mean weight at study initiation: ♀ = 150g; ♂ = 160g
- Diet: ad libitum (Altromin "R" from Altromin GmbH, Lage)
- Water: ad libitum
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 10 - 21.3 ml/kg bw
DOSAGE PREPARATION (if unusual):
The test substance was administered as a 20 and 30% aqueous solution - Doses:
- 2, 2.5, 3.2, 4, 5, 6.4 ml/kg bw
conversion with density 0.99g/ml) = 1980, 2475, 3168, 3960, 4950, 6336 mg/kg bw - No. of animals per sex per dose:
- 5/sex/dose for all doses except 3168 mg/kg bw where 10/sex/dose were employed
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of mortality check: after 1 hour, 24 hours, 48 hours, 7 days and 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 3 455.1 mg/kg bw
- 95% CL:
- 2 978.9 - 4 007.5
- Remarks on result:
- other: At all doses symptoms included: apathy, dyspnoea, partly cyanosis, intermittent breathing, crouching position, agitation.
- Mortality:
- - 1980 mg/kg bw: 1/5♀, 0/5♂
- 2475 mg/kg bw: 1/5♀, 0/5♂
- 3168 mg/kg bw: 5♀, 3♂
- 3960 mg/kg bw: 5/5♀, 3/5♂
- 4950 mg/kg bw: 3/5♀, 4/5♂
- 6336 mg/kg bw: 5/5♀, 5/5♂ - Clinical signs:
- other: At all doses symptoms included: apathy, dyspnoea, partly cyanosis, intermittent breathing, crouching position, agitation.
- Gross pathology:
- - Decedents: liquid accumulation in the abdomen (10 animals), smudgy snout (4 animals), liver necrosis (1 animal)
- Sacrificed animals: multiple cases (9 animals) of reduced retroperitoneal fat pads, distended gastrointestinal tract
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.