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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Melting point / freezing point
Administrative data
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30 AUG 2022 TO 05 OCT 2022
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- boiling point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30 AUG 2022 TO 05 OCT 2022
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.2 (Boiling Temperature)
- Version / remarks:
- November 2019
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 103 (Boiling Point)
- Version / remarks:
- July 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7220 (Boiling Point / Boiling Range)
- Version / remarks:
- August 1996
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- differential scanning calorimetry
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- lot/batch number of test material: 22BN0551
- Expiry date: 28 April 2023 (retest date)
- Physical Description: Off-white powder
- Purity: 98.3%
- Purity correction factor: no correction factor required
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: At room temperature
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Final preparation of a solid: not applicable, the solid test item was transferred directly into the DSC cell - Key result
- Atm. press.:
- 1 atm
- Decomposition:
- yes
- Decomp. temp.:
- 225 °C
- Remarks on result:
- other: Boiling of the test material was not observed below the temperature at which reaction and/or decomposition started. Based on this, the test material has no boiling temperature.
- Conclusions:
- The boiling temperature of JNJ-63632283-AAA (T003665) were tested by DSC.
Reaction and/or decomposition of the test material was observed during DSC experiment starting at 225°C. Boiling of the test material was not observed below the temperature at which reaction and/or decomposition started. Based on this, the test material has no boiling temperature.
Preliminary test
From the TGA curve it could be derived that starting at at 225°C, the weight of the sample decreased significantly. At 289°C, the sample weight had decreased by 25%. After the experiment, a dark brown molten residue remained in the sample container (original colour: off-white). The change of the colour indicated reaction and/or decomposition of the test material.
Many study
From the DSC curce obtained with Experiment 1, an endothermic effect was observed between 125°C and 150°C. The extrapolated onset temperature of the effect was 133.453°C. The endothermic effect was most likely obtained due to melting of the test material. Starting from 225°C, an exothermic effect was observed. It was most likely due to reaction and/or decomposition of the test material. After the experiment, a dark brown molten residue remained in the sample container (original colour: off-white).
In order to investigate the endothermic effect, Experiment 2 was stopped directly after the melting effect. During Experiment 2 a technical error in the equipment occurred. Therefore, the results of Experiment 2 were discarded.
Experiment 3 was performed to investigate the endothermic effect found in Experiment 1 and was directly stopped after the melting effect. From the DSC curve obtained, the extrapolated onset temperature was 133.426°C. After the experiment, a molten off-white residue remained in the sample container (original colour: off-white). It demonstrated that melting was the reason for the endothermic effect.
Boiling of the test material was not observed below the temperature at which reaction and/or decomposition started. Based on this, the test material has no boiling temperature.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 022
- Report date:
- 2022
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Version / remarks:
- November 2019
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Version / remarks:
- July 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7200 (Melting Point / Melting Range)
- Version / remarks:
- March 1998
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- differential scanning calorimetry
Test material
- Reference substance name:
- 1-amino-N-[6-cyano-5-(trifluoromethyl)-3- pyridyl]cyclobutanecarboxamide
- Cas Number:
- 1950587-17-3
- Molecular formula:
- C12H11F3N4O
- IUPAC Name:
- 1-amino-N-[6-cyano-5-(trifluoromethyl)-3- pyridyl]cyclobutanecarboxamide
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Name of test material: JNJ-63632283-AAA (T003665)
- Physical state: solid (powder)
- Appearance: white powder
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- lot/batch number of test material: 22BN0551
- Expiry date: 28 April 2023 (retest date)
- Physical Description: Off-white powder
- Purity: 98.3%
- Purity correction factor: no correction factor required
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: At room temperature
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Final preparation of a solid: not applicable, the solid test item was transferred directly into the DSC cell
Results and discussion
Melting / freezing point
- Key result
- Melting / freezing pt.:
- 133.4 °C
- Atm. press.:
- 1 atm
- Decomposition:
- yes
- Decomp. temp.:
- 225 °C
Any other information on results incl. tables
Preliminary test
From the TGA curve it could be derived that starting at at 225°C, the weight of the sample decreased significantly. At 289°C, the sample weight had decreased by 25%. After the experiment, a dark brown molten residue remained in the sample container (original colour: off-white). The change of the colour indicated reaction and/or decomposition of the test material.
Many study
From the DSC curce obtained with Experiment 1, an endothermic effect was observed between 125°C and 150°C. The extrapolated onset temperature of the effect was 133.453°C. The endothermic effect was most likely obtained due to melting of the test material. Starting from 225°C, an exothermic effect was observed. It was most likely due to reaction and/or decomposition of the test material. After the experiment, a dark brown molten residue remained in the sample container (original colour: off-white).
In order to investigate the endothermic effect, Experiment 2 was stopped directly after the melting effect. During Experiment 2 a technical error in the equipment occurred. Therefore, the results of Experiment 2 were discarded.
Experiment 3 was performed to investigate the endothermic effect found in Experiment 1 and was directly stopped after the melting effect. From the DSC curve obtained, the extrapolated onset temperature was 133.426°C. After the experiment, a molten off-white residue remained in the sample container (original colour: off-white). It demonstrated that melting was the reason for the endothermic effect.
The melting temperature was determined as the mean melting temperature of Experiment 1 (133.453°C) and Experiment 3 (133.426°C).
Applicant's summary and conclusion
- Conclusions:
- The melting temperature of JNJ-63632283-AAA (T003665) was tested by DSC.
The melting temperature of the test material was 133.4°C.
Reaction and/or decomposition of the test material was observed during DSC experiment starting at 225°C.
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