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EC number: 700-054-1 | CAS number: 70905-68-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was carried out in compliance with the OECD Guideline for Testing of Chemicals No. 423 "Acute Oral Toxicity", 1996, and Directive 96/54/EEC, Part B.1 tris "Acute Toxicity - Oral Acute Toxic Class Method, 1996, with no deviations reported.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Swiss Federal Department of the Interior
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- (1S,4R,6R)-1-[(3E)-5-hydroxy-3-methylpent-3-en-1-yn-1-yl]-2,2,6-trimethylcyclohexane-1,4-diol
- EC Number:
- 700-054-1
- Cas Number:
- 70905-68-9
- Molecular formula:
- C15H24O3
- IUPAC Name:
- (1S,4R,6R)-1-[(3E)-5-hydroxy-3-methylpent-3-en-1-yn-1-yl]-2,2,6-trimethylcyclohexane-1,4-diol
- Reference substance name:
- (1S,4R,6R)-1-[(E)-5-Hydroxy-3-methyl-3-penten-1-ynyl]-2,2,6-trimethyl-1,4-cyclohexanediole
- IUPAC Name:
- (1S,4R,6R)-1-[(E)-5-Hydroxy-3-methyl-3-penten-1-ynyl]-2,2,6-trimethyl-1,4-cyclohexanediole
- Details on test material:
- - Name of test material (as cited in study report): Triol
- Physical state: white solid
- Analytical purity: 99.5 % (LC), 99.8 % (DSC)
- Lot/batch No.: 6262/ZTN/03/N/08/001/003
- Expiration date of the lot/batch: 1 December 2000
- Stability under test conditions: not specified in polyethylene glycol
- Storage condition of test material: in refridgerator at 4 +/- 3 °C, protected from sunlight
- Other:
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- other: HanIbm: WIST (SPF)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: RCC Ltd., Biotechnology & Animal Breeding Division, Füllinsdorf, Switzerland
- Age at study initiation: 8-10 weeks
- Weight at study initiation: 227.3-229.5 g (males), 156-167.7 g (females)
- Fasting period before study: overnight prior to treatment
- Housing: groups of three in Makrolon type-4 cages with standard softwood bedding (Lignocel, Schill AG, Muttenz, Switzerland)
- Diet (e.g. ad libitum): pelleted standard Kliba 3433 (batch 43/99) (Provimi Kliba AG, Kaiseraugst, Switzerland) ad libitum
- Water (e.g. ad libitum): community tap water from Füllinsdorf ad libitum
- Acclimation period: one week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22-24
- Humidity (%): 40-70
- Air changes (per hr): 10-15
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: To:
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- polyethylene glycol
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 0.2 g/mL
- Amount of vehicle (if gavage): 10 mL/kg - Doses:
- 2000 mg/kg bodyweight
- No. of animals per sex per dose:
- three males, three females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observations for mortality/viability: ten minutes (females), one, two, three and five hours after treatment on test day 1, and twice daily during days 2-15; bodyweight: test day one (before treatment), 8 and 15; clinical signs: five times (females) and four times (males) on day one, once daily during days 2-15
- Necropsy of survivors performed: yes - Statistics:
- No statistical analysis was used.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- No deaths occurred during the study.
- Clinical signs:
- other: Dyspnea and weak activity were noted in one female within ten minutes and one hour after treatment. Slight ruffled fur and weak activity were observed in all female animals two hours after article administration. Slight ruffled fur was noted in all mal an
- Gross pathology:
- No macroscopic findings were observed at necropsy.
Any other information on results incl. tables
Table 1: Bodyweights of the individual animals during the test (g).
Bodyweights in g |
||||
Sex/Dose |
Animal no. |
Day 1 |
Day 8 |
Day 15 |
Females 2000 mg/kg bw |
1 |
156.0 |
173.9 |
189.3 |
2 |
161.5 |
180.2 |
193.5 |
|
3 |
167.7 |
195.5 |
210.8 |
|
Males 2000 mg/kg bw |
4 |
229.4 |
261.2 |
283.9 |
5 |
227.3 |
276.0 |
300.2 |
|
6 |
229.5 |
264.8 |
300.7 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information
- Conclusions:
- The median lethal dose of Triol after single oral administration to rats of both sexes, observed over a period of 14 days is: LD50 > 2000 mg/kg bodyweight.
- Executive summary:
The acute oral toxicity of Triol to the rat was tested with the acute toxic class method according to the OECD Guideline No. 423 and Directive 96/54/EEC B.1 tris. Two groups, each using thre male or three female HanIbm: WIST (SPF) rats, were treated with Triol at 2000 mg/kg bodyweight by a single dose via oral gavage. The test article was suspended in polyethylene glycol (PEG 300) at a concentration of 0.2 g/mL and administered at a volume of 10 mL/kg. The animals were examined for clinical signs four to five times during day 1 and once daily during test days 2 -15. Mortality/viability was recorded together with clinical signs at the same time intervals on test day 1 and then twice daily on test days 2 -15. Bodyweights were recorded on day 1 before administration and days 8 and 15. All animals were subjected to necropsy and examined macroscopically.
No deaths occurred during the study. Dyspnea and weak activity were noted in one female animal (no. 1) within ten minutes and one hour after treatment. Slight ruffled fur and weak activity were observed in all female animals two hours after test article administration. Slight ruffled fur was noted in all male animals from 2 to 5 hours after treatment.
The bodyweight of the animals was within the range commonly recorded for animals of this strain and age.
No macroscopic findings were observed at necropsy.
The median lethal dose of Triol after single oral administration to rats of both sexes, observed over a period of 14 days, is: LD50 > 2000 mg/kg bodyweight.
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