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EC number: 430-380-7 | CAS number: 445409-27-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study conducted similar to OECD Guideline under GLP conditions. Study report does not specifically identify test guideline followed, however, evaluation of the full study supports that the study is conducted similar to OECD test guidelines.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.2500 (Acute Dermal Irritation)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Molyvan 855 (OD-855)
- IUPAC Name:
- Molyvan 855 (OD-855)
- Reference substance name:
- -
- EC Number:
- 430-380-7
- EC Name:
- -
- Cas Number:
- 445409-27-8
- Molecular formula:
- Cannot be assigned due to being a complex reaction mixture
- IUPAC Name:
- Amides, coco, N, N-bis(hydroxyethyl), reaction products with coco monoglycerides and molybdenum oxide
- Details on test material:
- - Name of test material (as cited in study report):
OD-856 Organomolybdenum mixture
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source:
Approved supplier
- Age at study initiation:
Young adult
- Weight at study initiation:
2.40 +/- 0.14 KG
- Housing:
All housing and care conformed to the standards established in "Guide for the care and Use of Laboratory Animals" DHEW Publications No. (NIH) 85-23.
- Diet (e.g. ad libitum):
Certified rabbit feed ad libitum
- Water (e.g. ad libitum):
Tap water ad libitum
- Acclimation period:
ENVIRONMENTAL CONDITIONS
- Temperature (°C):
Room temperature
- Photoperiod (hrs dark / hrs light):
12 Hour light dark cycle maintained.
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 0.5 ml
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 4.5, 28, 52 and 76 hours post-exposure
4, 7, 10 and 14 days post exposure - Number of animals:
- 6
- Details on study design:
- On the day prior to dosing, the back of each rabbit was clipped free of fur with electric clippers. During this procedure, care was taken to avoide accidental abrasion to the skin. On the day of dosing. a volume of 0.5 ml of the test article was applied to each of 2 test sites. Following application, each test site was occluded with a one-inch square gauze patch held in place with Blenderm(r) tape.
Four hours post-dose, the patches were removed. The exposure sites were gently wiped with clean gauze to remove as much non-absorbed test article as possible. One half hour after unwrapping, the exposure sites were examined and scored separately for both erythema and edema on a graded sc all of 0 to 4 in accordance with the Skin Reaction Code. The exposure sites were again examined and scored at 28, 52 and 76 hours post-dose. Any signs of irritation were noted and observations were made on day 4, 7, 10 and 14 or until all sites returned to normal. Any extraordinary finding. dermal or toxicological, were noted.
In evaluation the average irritation, scores for individual intact exposure sites were recorded separately for each of the scoring time intervals. Based on the 28, 52 and 76 hour observations, a total for erythema and eschar formation was added to a total for edema, then divided by 6 to yield individual animal score. The mean of the six scores was calculated and this score represents the mean primary score.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 76 hours post dosing
- Score:
- 0.73
- Max. score:
- 8
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- overall irritation score
- Basis:
- animal #1
- Time point:
- other: 76 hours post dosing
- Score:
- 1
- Max. score:
- 8
- Irritation parameter:
- overall irritation score
- Basis:
- animal #2
- Time point:
- other: 72 hours post dosing
- Score:
- 1.2
- Max. score:
- 8
- Irritation parameter:
- overall irritation score
- Basis:
- animal #3
- Time point:
- other: 72 hours post dosing
- Score:
- 0.83
- Max. score:
- 8
- Irritation parameter:
- overall irritation score
- Basis:
- animal #4
- Time point:
- other: 72 hours post dosing
- Score:
- 0.67
- Max. score:
- 8
- Irritation parameter:
- overall irritation score
- Basis:
- animal #5
- Time point:
- other: 72 hours post dosing
- Score:
- 0.33
- Max. score:
- 8
- Irritation parameter:
- overall irritation score
- Basis:
- animal #6
- Time point:
- other: 72 hours post dosing
- Score:
- 0.33
- Max. score:
- 8
- Irritant / corrosive response data:
- Slight erythema and eschar formation was the primary effect observed in animals up until 76 hours post dosing. Slight edema formation was observed in two animals post dosing up to 28 hours post dosing.
- Other effects:
- One animal died on day 8 and another on day 14. Prior to death of the above two animals, anorexia and diarrhea were observed. No lesions or abnormalities were noted in these animals at gross necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: other: Modification of J. Soc. Cosmet. Chem. Vol 13, No 6. 1962, p. 281 - 289
- Conclusions:
- Molyvan 855 is slightly irritating under the conditions of this study.
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