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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- not specified
- GLP compliance:
- no
- Test type:
- fixed concentration procedure
Test material
- Reference substance name:
- Reaction mass of Trihydrogen [29H,31H-phthalocyaninetrisulphonato(5-)-N29,N30,N31,N32]cobaltate(3-) and [29H,31H-phthalocyaninato-N29,N30,N31,N32]cobalt and dihydrogen [29H,31H-phthalocyaninedisulphonato(4-)-N29,N30,N31,N32]cobaltate(2-) and hydrogen [29H,31H-phthalocyaninesulphonato(3-)-N29,N30,N31,N32]cobaltate(1-)
- Molecular formula:
- C32H16N8Co(SO3)n with n=0 to 3
- IUPAC Name:
- Reaction mass of Trihydrogen [29H,31H-phthalocyaninetrisulphonato(5-)-N29,N30,N31,N32]cobaltate(3-) and [29H,31H-phthalocyaninato-N29,N30,N31,N32]cobalt and dihydrogen [29H,31H-phthalocyaninedisulphonato(4-)-N29,N30,N31,N32]cobaltate(2-) and hydrogen [29H,31H-phthalocyaninesulphonato(3-)-N29,N30,N31,N32]cobaltate(1-)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- The test group consisted of randomly selected five male and five female Sprague-Dawley derived CD® rats obtained from Charles River Breeding Laboratories, Kingston, New York on May 5, 1981.
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Mass median aerodynamic diameter (MMAD):
- ca. 4.64 µm
- Geometric standard deviation (GSD):
- ca. 11.44
- Details on inhalation exposure:
- The test material was first ground with a mortar and pestle then sieved through a 60 mesh (Tyier equivalent) sieve. The test material was then press-packed into a Wright Oust Feed cylinder using a Carver Laboratory Hydraulic Press at a pressure of 1800-2000 pounds per square inch (psi). The cylinder was mounted on a Wright Dust Feed mechanism. Dry air, at an airflow rate of 15.0 liters per minute (lorn), was delivered to the dust feed mechanism and the test atmosphere was then directed, undiluted, into a 100 liter.
Plexiqlas® chamber housing the test animals. The exposure lasted for four hours.
The dust cylinder, base cap, blade, and test material were weighed before and after the exposure. The difference in weight represented the total amount of test material delivered into the chamber; this, divided by the total volume of air delivered yielded the nominal exposure concentration.
Chamber air samples were drawn at approximately hourly intervals at a rate of 2.9 1pm for 3.0 or 2.0 minutes using a Millipore filter holder and a glass microfibre filter. In addition, a set of gravimetric samples was drawn to determine the distribution of the test material in the chamber. The amount of material collected was determined qravimetrically by weighing the filter holder and filter paper before and after samplinq and dividing the difference in weight by the sample volume (8.7 or 5.8 1).
Particle size distribution samples were taken using a Casella cascade impactor at approximately half-hour intervals throughout the exposure.
The distribution was calculated based on the amount of material collected on the impactor stages (glass slides).
A wet-bulb/dry-bulb hygrometer was used to monitor chamber air temperature and relative humidity which was recorded hourly throughout the exposure. - Duration of exposure:
- ca. 4 h
- Concentrations:
- 18.2 mg/l
- No. of animals per sex per dose:
- 5 per sex and per dose
- Control animals:
- no
- Details on study design:
- The animals were observed for abnormal signs before exposure, approximately every fifteen minutes during the first hour of the exposure hourly during the remainder of the exposure period, upon removal from the chamber, hourly for four hours post-exposure, and daily thereafter for 14 days. Individual body weights for all rats were scheduled to be recorded on Days 0 (prior to exposure), 1, 2, 4, 7, and 14. On Day 14 (June 5, 1981), all surviving rats were exsanguinated under ethyl ether anesthesia and gross necropsy examinations were performed.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 18.2 mg/L air
- Mortality:
- Two animals (#1048M and #1547F) died on Days 2 and 3, respectively, as a result of test material exposure.
- Clinical signs:
- other: Few rats exhibited lacrimation, mucoid nasal discharge, salivation, rough coat, swollen eyelids, and gasping during the exposure period. These responses commenced after 15 minutes of exposure. After removal from the exposure chamber, some rats exhibited l
- Body weight:
- Although small, transient weight-losses were seen in most of the eight surviving rats (due to exposure procedure), the body weights recovered to pre-exposure values in most males and a11 females by Day 7. Body weight increments in the second week were within the limits of normal expectation for both sexes.
- Gross pathology:
- At necropsy, the two rats that died due to exposure, had lunq discoloration. Most of the eiqht surviving rats also had lunq discoloration as well as discoloration of the mucosa of the stomach, esophagus, and qastrointestinal tract. These observations are indicative of exposure related effects.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- A four-hour acute inhalation exposure to a dust of Cobalt Phthalocyam'ne Sulfonate at a nominal concentration of 18.2 mq/1 and a mean airborne concentration of 1.05 mg/1 resulted in the death of two animals and caused slight immediate reversible irritation of the ocular and respiratory mucous membranes in the surviving animals.
Post-mortem findings revealed lung discoloration in most rats which indicates a residual effect from exposure.
Under tests conditions, test item do not require classification for acute inhalation toxicity according to GHS criteria.
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