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EC number: 686-526-7 | CAS number: 171611-11-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018.01.16~2018.11.18
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD TG422(Combined Repeated dose toxicity study with reproduction/developmental toxicity screening test"
- Version / remarks:
- 29 july 2016
- GLP compliance:
- yes
- Type of method:
- in vivo
Test material
- Reference substance name:
- Lithium bis(fluorosulfonyl)imide
- EC Number:
- 686-526-7
- Cas Number:
- 171611-11-3
- Molecular formula:
- F2 H N O4 S2 . Li
- IUPAC Name:
- Lithium bis(fluorosulfonyl)imide
- Test material form:
- solid: bulk
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: distilled water
- Analytical verification of doses or concentrations:
- yes
- Details on analytical verification of doses or concentrations:
- Analysis was performed before treatment (1st dosing) based on the analytical method
validation (KTR Study No. TBK-001907-2017), Analytical method validation of the LiFSI
in dosing formulation by using ICP-OES. The results were as follows and were met
the acceptance criteria as follows (precision: less than 10 %, accuracy: 80 – 120 %);
Homogeneity – 1.71 %, 2.10 %, 0.88 %, Concentration – 101.92 %, 104.35 %, 104.35 %) - Duration of treatment / exposure:
- 7d/week
- Frequency of treatment:
- once/day
Doses / concentrationsopen allclose all
- Dose / conc.:
- 0 mg/kg bw/day (nominal)
- Dose / conc.:
- 45 mg/kg bw/day (nominal)
- Dose / conc.:
- 90 mg/kg bw/day (nominal)
- Dose / conc.:
- 180 mg/kg bw/day (nominal)
- No. of animals per sex per dose:
- ) 0 mg/kg bw/day "Control animal"
- Male(17), Female(17)
2) 45mg/kg bw/day
- Male (12)/ Female(12)
3) 90mg/kg bw/day
- Male(12)/Female(12)
4) 180mg/kg bw/day
- Male(17) / Female(17) - Control animals:
- yes
- Statistics:
- liver discoloration (median, left lateral lobe –Animal No. 1203) at male 45 mg/kgㆍbw/day group,
small seminal vesicle, right –Animal No. 1402) at male 180 mg/kgㆍbw/day group, liver notch and discoloration
(whole lobe – Animal No. 2102) at female control group, kidney notch (both sides –Animal No. 2304) at female 90 mg/kgㆍbw/day.
Also, gross abnormalities were not observed in recovery group at any dose group
Results and discussion
Effect levels
- Key result
- Dose descriptor:
- NOAEL
- Effect level:
- ca. 90 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- male/female
Observed effects
female and male rats at doses of 0, 45, 90 and 180 mg/kg·bw/day before and
during mating (both sexes) and during gestation and for 13 days of lactation
(females). The administration-related toxicity for reproductive/development was 180
mg/kg·bw/day based on live birth index (PND 0), viability index (PND 4) and number
of live pup at PND 4.
In conclusion, the NOAEL(No Observed Adverse Effect Level) for repeated-dose
toxicity was 180 mg/kgㆍbw/day and the NOAEL for reproductive/developmental
toxicity was 90 mg/kgㆍbw/day. based on no evidence of reproductive toxicity.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.