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Diss Factsheets
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EC number: 209-665-3 | CAS number: 589-92-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Boiling point
Administrative data
Link to relevant study record(s)
- Endpoint:
- boiling point
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1973
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- No details on the method used or experimental setup. Substance identity confirmed spectroscopically.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- No details on the method used were reported.
- GLP compliance:
- no
- Type of method:
- other: method not reported
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: A sample of 4-methylcyclohexanone was prepared as reference material, according to the method by Pezold M. et al, J. Amer. Chem. Socl, 64, 4707 (1932). Substance identity was confirmed with H-NMR, IR and comparison to literature boiling point. - Key result
- Boiling pt.:
- >= 169 - <= 170 °C
- Atm. press.:
- ca. 1 atm
- Conclusions:
- The boiling point for 4-methylcyclohexanone was reported as 169-170°C at atmospheric pressure.
- Executive summary:
The boiling point for 4-methylcyclohexanone prepared as a chromatography reference material was reported as 169-170°C at atmospheric pressure.
- Endpoint:
- boiling point
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1965
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- No details on the method used or experimental setup. Some details given on sample purification.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- No details were reported on the method used.
- GLP compliance:
- no
- Type of method:
- distillation method
- Remarks:
- assumed to be distillation method
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Eastman Organic Chemicals - Key result
- Boiling pt.:
- >= 168 - <= 171 °C
- Atm. press.:
- ca. 1 atm
- Conclusions:
- The boiling point for 4-methylcyclohexanone, measured as part of a purification by double distillation, was reported as 168-171°C.
- Executive summary:
The boiling point for 4-methylcyclohexanone was reported as 168-171°C.
- Endpoint:
- boiling point
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1938
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- No details on the method used or experimental setup. Some details on sample purification provided.
- Principles of method if other than guideline:
- no information on the technical method given.
- GLP compliance:
- no
- Type of method:
- other: method not reported
- Specific details on test material used for the study:
- Commercially available 4-Methylcyclohexanone was purified as follows:
4-Methylcyclohexanone was treated with a freshly prepared oversaturated filtered solution of sodium hydrogene sulfite. After shaking strongly for 3 hours the system was frozen. The next day, the solid parts were dried and washed extensively with cold ether. As soon as dried, the bisulfite derivates were decomposed with sodium carbonate. The 4-methylcyclohexanone released was rectified systematically by powerful Crismer Columns (35 spires) with external heating. - Boiling pt.:
- 171.25 °C
- Atm. press.:
- 760 mm Hg
- Conclusions:
- The boiling point for 4-methylcyclohexanone was reported as 171.25°C at 760mmHg. No method was reported in the publication for the method used.
- Executive summary:
The boiling point for purified 4-methylcyclohexanone was reported as 171.25°C at 760mmHg.
Referenceopen allclose all
The pressure was not explicitly reported, but was assumed by the registrant to be atmospheric pressure.
Pressure assumed by the registrant to be atmospheric. The refractive index of the twice distilled test material was measured to be 1.4429.
no information on method in the publication.
Description of key information
Three representative publications were selected from the available literature reporting a boiling point for 4-methylcyclohexanone:
168 -171°C, ca. 1 atm, distillation (Elliott, 1965)
171.25°C, 760mmHg, method not reported (Chiurdoglu, 1938)
169 -170, ca. 1 atm, method not reported (Kwart, 1973)
All three primary data sources were assigned a Klimisch reliability rating of 4, due to the lack of experimental details reported in the publications. The values reported by the three independent research groups, measured on independently synthesised samples, at different times, are all in very good agreement. As a result, in accordance with REACH, Annex XI, 1.2, this standard data requirement is considered to be met based on the weight of evidence. Overall the available data is considered to be adequate, relevant, and reliable, and no further testing is required for this endpoint. Because a specific value is required to be reported (as opposed to a range), the average of the above averaged values was taken, and carried forward for the purposes of risk assessment and classification.
Key value for chemical safety assessment
- Boiling point at 101 325 Pa:
- 170 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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