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EC number: 613-816-2 | CAS number: 6553-64-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The oral LD50 of the test substance is 500 mg/kg bw in rats.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 28 February to 21 March 2006
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- Study conducted in compliance with OECD Guideline 423 without any deviation but not under GLP.
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- no
- Test type:
- acute toxic class method
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Elevage Janvier, Le Genest-Saint-Isle, France
- Weight at study initiation: 192-235 g
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature: 20-23°C
- Humidity: 30-53 % - Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 2000 mg/kg bw
300 mg/kg bw - No. of animals per sex per dose:
- - Batch 1 (control): 6 rats females
- Batch 2 (2000 mg/kg): 3 rats females
- Batch 3 (300 mg/kg): 6 rats females - Control animals:
- yes
- Statistics:
- None
- Preliminary study:
- Not Applicable
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 500 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality was observed at dose 300 mg/kg bw
Death was observed for the 3 rats treated at dose 2000 mg/kg bw - Clinical signs:
- No clinical signs related to the administration of the test item were observed at dose 300 mg/kg bw.
A reduction in spontaneous activity, muscle tone and righting reflex were observed during the first hours of the treatment for the animals treated at 2000 mg/kg bw. - Body weight:
- Body weight gain of the treated animals was not affected by test item at dose 300 mg/kg bw
- Gross pathology:
- At 2000 mg/kg bw, red coloration was observed in the fundic mucosa of the stomach. At 300 mg/kg bw, white thickening of the ventricular mucosa was observed in the stomach.
- Other findings:
- None
- Interpretation of results:
- Category 4 based on GHS criteria
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The oral LD50 for 6,6-DIMETHYL-2-CYCLOHEXENONE is 500 mg/kg bw in female rats therefore it is classified in category 4 (H302) according to CLP Regulation (EC) No 1272/2008.
- Executive summary:
In an acute oral toxicity study performed according to OECD Guideline 423 (using acute toxic class method), Sprague Dawley female rats were treated with two doses, 2000 and 300 mg/kg bw by gavage. Animals were then observed for mortality, clinical signs and bodyweights and were all sacrificed for macroscopic examination.
No mortality was observed at dose 300 mg/kg bw and death was observed for the 3 rats treated at dose 2000 mg/kg.
No clinical signs related to the administration of the test item were observed at dose 300 mg/kg bw. Body weight gain of the treated animals was not affected by test item at dose 300 mg/kg bw.
Animals treated at 2000 mg/kg showed a reduction in spontaneous activity, muscle tone and righting reflex during the first hours of the treatment.
In this study, the oral LD50 of 6,6-DIMETHYL-2-CYCLOHEXENONE was considered to be 500 mg/kg bw in female rats.
Therefore, 6,6-DIMETHYL-2-CYCLOHEXENONE is lassified in category 4 (H302) according to CLP Regulation (EC) No 1272/2008.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 500 mg/kg bw
- Quality of whole database:
- GLP study conducted according to OECD TG 423
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In an acute oral toxicity study performed according to OECD Guideline 423 (using acute toxic class method), Sprague Dawley female rats were treated with two doses, 2000 and 300 mg/kg bw by gavage. Animals were then observed for mortality, clinical signs and bodyweights and were all sacrificed for macroscopic examination.
No mortality was observed at dose 300 mg/kg bw and death was observed for the 3 rats treated at dose 2000 mg/kg bw.
No clinical signs related to the administration of the test item were observed at dose 300 mg/kg. Body weight gain of the treated animals was not affected by test item at dose 300 mg/kg bw.
Animals treated at 2000 mg/kg bw showed a reduction in spontaneous activity, muscle tone and righting reflex during the first hours of the treatment.
Justification for classification or non-classification
The oral LD50 of the registered substance is 500 mg/kg bw in rats. Therefore it is classified in category 4 (H302) according to CLP Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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