Bis(5-oxo-L-prolinato-N1,O2)zinc

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

07 March 2017 to 15 March 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

static method

Specific details on test material used for the study:

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Controlled room temperature (15 to 25 °C, below 70 RH %), protected from light

Key result

Temp.:

20 °C

Vapour pressure:

475 Pa

Run 1- Sample weight 20.813 grams.

The sample was degassed over 48 hours. A vacuum of 0.0011 mbar was obtained on the system prior to the start of the test. It was not possible to obtain a stable reading at 40 °C. An initial reading of 0.5062 mbar was obtained at 40 °C, this increased to 3.6 mbar over the next 5 hours. The test was discontinued. The instability in the sample could be due to the release of water from the sample.

Run 2- Sample weight 19.04 grams.

A direct reading was taken due to the nature of the material. A vacuum of 0.0180 mbar was obtained on the system prior to the start of the test. The sample was allowed to equilibrate for 5 hours and 20 hours with measurements of 4.8 mbar and 5.2 mbar observed respectively.

Run 3- Sample weight 18.55 grams.

A direct reading was taken due to the nature of the material. A vacuum of 0.0165 mbar was obtained on the system prior to the start of the test. The sample was allowed to equilibrate for 5 hours and 21 hours with measurements of 4.7 mbar and 5.1 mbar observed respectively. The vapour pressure was monitored over the next 48 hours and found to consistently increase by approximately 2 mbar every 24 hours. Therefore the initial readings after 5 hours have been reported.

Due to the extended degassing period of test run 1 and suspected evolution of water it is suspected that the results are unreliable. Therefore the mean of the initial direct measurements taken at 20 °C for runs 2 and 3 has been reported as the vapour pressure.

Table 1: Full test results

Temperature (°C)	Temperature (K)	Pressure (mbar)	Calculated Pressure (Pa)
Run 1
*20	293.15	0.04	4
20.4	293.55	0.0431	4.31
30.1	303.25	0.2073	20.73
Run 2
20	293.15	4.8	480
Run 3
20	293.15	4.7	470

*Determined by extrapolation from run 1

Conclusions:

Under the conditions of the study the vapour pressure of the test material was 475 Pa at 20 °C.

Executive summary:

The vapour pressure of the test material was determined in accordance with the standardised guideline EU Method A.4. The test was performed using a static method under GLP conditions.

This method involves placing a quantity of the test material in the sample chamber of the glassware and a suitable manometer liquid in the U-tube. The contents of the static glassware are connected to a vacuum system linked with pressure monitors to enable the reading of any pressure/ vacuum on the contents of the static glassware.

An extended degassing period and suspected evolution of water was suspected in test run 1 and as a result was deemed unreliable. Therefore the mean of the initial direct measurements taken at 20 °C for runs 2 and 3 has been reported as the vapour pressure.

Under the conditions of the study the vapour pressure of the test material was 475 Pa at 20 °C.

Description of key information

Under the conditions of the study the vapour pressure of the test material was 475 Pa at 20 °C.

Key value for chemical safety assessment

Vapour pressure:

475 Pa

at the temperature of:

20 °C

Additional information

The vapour pressure of the test material was determined in accordance with the standardised guideline EU Method A.4. The test was performed using a static method under GLP conditions. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).

This method involves placing a quantity of the test material in the sample chamber of the glassware and a suitable manometer liquid in the U-tube. The contents of the static glassware are connected to a vacuum system linked with pressure monitors to enable the reading of any pressure/ vacuum on the contents of the static glassware.

An extended degassing period and suspected evolution of water was suspected in test run 1 and as a result was deemed unreliable. Therefore the mean of the initial direct measurements taken at 20 °C for runs 2 and 3 has been reported as the vapour pressure.

Under the conditions of the study the vapour pressure of the test material was 475 Pa at 20 °C.