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Diss Factsheets
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EC number: 214-686-6 | CAS number: 1185-57-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- for read across substance
- Justification for type of information:
- Data for the target chemical is summarized based on the structurally similar read across chemicals
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- WoE was prepared from the two different studies, to determine the effect of test chemical on the growth of algae.
- GLP compliance:
- not specified
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- other: Test conducted on Scenedesmus quadricauda and Green algae
- Details on test organisms:
- WoE 2: TEST ORGANISM
- Common name: Green Algae
- Source (laboratory, culture collection): laboratory - Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 7 d
- Test temperature:
- 27 ° C
- Details on test conditions:
- 1) TEST SYSTEM
- Test vessel: Erlenmeyer flasks
- Type (delete if not applicable): closed
Filled culture tubes were maintained at 27°C and relative humidity of 50%. The concentration of the algal suspension is measured turbidmetrically (while diffused light is screened off) and expressed by the extinction of the primary light of the monochromatic radiation at 578 nm for a layer of 10 mm thickness. - Reference substance (positive control):
- not specified
- Duration:
- 7 d
- Dose descriptor:
- other: TTsc
- Effect conc.:
- 640 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: toxicity threshold of Scendesmus quadricauda (green algae) TTsc
- Remarks:
- WoE 2
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: WoE 3
- Details on results:
- WoE 2: TT ( toxicity threshold ) = 640 mg/L
Toxicity threshold is defined as the pollutant concentration resulting in a mean extinction value that is ≥3% below the mean of the extinction value for the non-toxic dilutions of the test culture. - Validity criteria fulfilled:
- not specified
- Conclusions:
- Under the test condition and on the basis of effects observation on the different species of green algae, it is observed that the test does not shows any toxicity atleast in the concentrations range of 100-640 mg/l.
- Executive summary:
Data available for the test chemical have been reviewed to determine the toxicity of test chemical on aquatic algae. The studies are as mentioned below:
The cell multiplication inhibition of green algae Scenedesmus quadricauda by the test chemical exposure for 7 days was performed. Test conducted under the static system on nominal test concentration. Test solutions prepared in the Erlenmeyer flasks in which the stock solution was added obtain from the laboratory. Before preparing the test cultures, the solution has been neutralize having a known pollutant content in sterile double-distilled water to be tested using the minimum volume acid or alkaline solution. After the exposure period of 7 days, turbidity and colourations were observed. Effects on the growth of test organism Scenedesmus quadricauda was observed on the basis of toxicity threshold of green algae (TTsc). The toxicity threshold of Scendesmus quadricauda (green algae) TTsc when exposed to test material for 7 days was 640 mg/L. Based on the above effects, can be concluded that the test chemical was nontoxic.
Above study was further supported by the study from authoritative database. Principle of this study was to observe the effect of test chemical on the growth of aquatic algae. Study conducted under the static system for 72 hours in accordance with OECD Guideline 201 (Alga, Growth Inhibition Test). After the exposure period of test chemical with green algae, effects on the growth of algae was calculated. Based on the growth rate inhibition of aquatic algae by the chemical exposure for 72 hours, the EC50 and NOEC was observed to > 100 mg/l and ≥ 100 mg/l, respectively. Thus based on the EC50 value, it is concluded that the test chemical was nontoxic and not classified as per the CLP classification criteria.
Thus based on the above both studies, it is observed that the test chemical was nontoxic and not classified as per the CLP classification criteria.
Reference
Description of key information
Under the test condition and on the basis of effects observation on the different species of green algae, it is observed that the test does not shows any toxicity atleast in the concentrations range of 100-640 mg/l.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 100 mg/L
Additional information
Data available for the test chemical, structurally and functionally similar read across chemicals have been reviewed to determine the toxicity of test chemical on aquatic algae. The studies are as mentioned below:
The cell multiplication inhibition of green algae Scenedesmus quadricauda by the test chemical exposure for 7 days was performed. Test conducted under the static system on nominal test concentration. Test solutions prepared in the Erlenmeyer flasks in which the stock solution was added obtain from the laboratory. Before preparing the test cultures, the solution has been neutralize having a known pollutant content in sterile double-distilled water to be tested using the minimum volume acid or alkaline solution. After the exposure period of 7 days, turbidity and colourations were observed. Effects on the growth of test organism Scenedesmus quadricauda was observed on the basis of toxicity threshold of green algae (TTsc). The toxicity threshold of Scendesmus quadricauda (green algae) TTsc when exposed to test material for 7 days was 640 mg/L. Based on the above effects, can be concluded that the test chemical was nontoxic.
Above study was further supported by the study from authoritative database. Principle of this study was to observe the effect of test chemical on the growth of aquatic algae. Study conducted under the static system for 72 hours in accordance with OECD Guideline 201 (Alga, Growth Inhibition Test). After the exposure period of test chemical with green algae, effects on the growth of algae was calculated. Based on the growth rate inhibition of aquatic algae by the chemical exposure for 72 hours, the EC50 and NOEC was observed to > 100 mg/l and ≥ 100 mg/l, respectively. Thus based on the EC50 value, it is concluded that the test chemical was nontoxic and not classified as per the CLP classification criteria.
Thus based on the above both studies, it is observed that the test chemical was nontoxic and not classified as per the CLP classification criteria.
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