Registration Dossier
Registration Dossier
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EC number: 609-306-4 | CAS number: 3689-69-8
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given: comparable to standards
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- HET-CAM
- GLP compliance:
- no
Test material
- Reference substance name:
- 6,10,14-Trimethyl-5-Pentadecen-2-on
- EC Number:
- 609-306-4
- Cas Number:
- 3689-69-8
- Molecular formula:
- C18H34O
- IUPAC Name:
- 6,10,14-Trimethyl-5-Pentadecen-2-on
- Details on test material:
- - Tetrahydrofarnesylaceton (THFAC), Substance-No.01/0753-1
- Batch No.: 01rg11.
- Purity: unknown
Constituent 1
- Specific details on test material used for the study:
- purity: ca. 95%
batch no.: 01rg11
Test animals / tissue source
- Species:
- other: chorionallantoic membrane of the hen's egg
Test system
- Vehicle:
- other: unchanged and 10% in olive oil
- Amount / concentration applied:
- undiluted and 10% in olive oil Ph.Eur./DAB
- Observation period (in vivo):
- 300 seconds
- Number of animals or in vitro replicates:
- 3
Results and discussion
Any other information on results incl. tables
The test substance was tested by means of the Hen's Egg Test - Chorioallantoic Membrane (HET-CAM) assay.
Evaluation: No risk of serious damage to eyes.
With the HET-CAM-Test in vitro the risk of serious damage to eyes can be determined. Possible eye irritancy cannot be evaluated in this system.
For non-isolated intermediates this limitation is considered to be acceptable.
Applicant's summary and conclusion
- Executive summary:
Time (seconds) until appearance of Concentration Egg-No. Haemorrhagia Lysis Coagulation Index for Irritation undiluted test substance 1 301 301 301 0 2 301 301 301 0 3 301 301 301 0 mean n=3 301 301 301 0 Time (seconds) until appearance of Concentration Egg-No. Haemorrhagia Lysis Coagulation Index for Irritation test substance 10% in olive oil Ph.Eur./DAB 1 301 301 301 0 2 301 301 301 0 3 301 301 301 0 mean n=3 301 301 301 0
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