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EC number: 226-033-2 | CAS number: 5235-82-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Solubility in organic solvents / fat solubility
Administrative data
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March 4, 2016 to September 2, 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 016
- Report date:
- 2016
Materials and methods
- Principles of method if other than guideline:
- Experimental Design:
Solubility of the test material at 250 mg/mL PG and approximately 5,000 μg/mL acetonitrile + 0.1% formic acid stored under ambient temperature, exposed to normal lighting conditions was assessed by visual inspection. - GLP compliance:
- yes
Test material
- Reference substance name:
- 4-[3-(1-naphthylamino)propyl]morpholine
- EC Number:
- 226-033-2
- EC Name:
- 4-[3-(1-naphthylamino)propyl]morpholine
- Cas Number:
- 5235-82-5
- Molecular formula:
- C17H22N2O
- IUPAC Name:
- N-[3-(morpholin-4-yl)propyl]naphthalen-1-amine
- Test material form:
- solid: granular
- Details on test material:
- Colour: Dark Brown to Black
GLP Characterized: January 21, 2016
Constituent 1
- Specific details on test material used for the study:
- Test Material Name: 4-(3-(1-naphthylamino)propyl)morpholine
Chemical Name: N-1-Naphthalenyl-4-morpholinepropanamine
Synonyms: None
Lot/Reference/Batch Number: ZA01212016
Purity/Characterization (Method of Analysis and Reference): The purity of the test material was determined to be 94.4% by liquid chromatography with identification by nuclear magnetic resonance spectroscopy and liquid chromatography mass spectrometry (Ferrer, 2016a). Standards were not corrected for purity.
Test Material Stability Under Storage Conditions: 4-(3-(1-Naphthylamino)propyl)morpholine, lot ZA01212016, was determined to be stable for 2 weeks at 54°C which is equivalent to 24 months under ambient storage conditions as tested under USEPA OPPTS Guideline 830.6313 (Ferrer, 2016b).
Results and discussion
Solubility in organic solvents / fat solubility
- Key result
- Medium:
- other: acetonitrile + 0.1% formic acid
- Solubility:
- 5 000 other: μg/mL
- Temp.:
- 23 °C
- Remarks on result:
- other: Solubility of 4-(3-(1-naphthylamino)propyl)morpholine (Lot # ZA01212016) has been demonstrated at a concentration of approximately 5,000 μg/mL in acetonitrile + 0.1% formic acid.
- Test substance stable:
- yes
- Details on results:
- Solubility was confirmed by visual inspection at a concentration of approximately 5000 μg/mL acetonitrile + 0.1% formic acid.
Applicant's summary and conclusion
- Conclusions:
- Solubility of 4-(3-(1-naphthylamino)propyl)morpholine (Lot # ZA01212016) has been demonstrated at a concentration of approximately 5,000 μg/mL in acetonitrile + 0.1% formic acid.
- Executive summary:
Solubility of the test material at 250 mg/mL PG and approximately 5,000 μg/mL acetonitrile + 0.1% formic acid stored under ambient temperature, exposed to normal lighting conditions was assessed by visual inspection.
A solubility assessment was performed by dissolving approximately 0.1 g of 4-(3-(1-naphthylamino)propyl)morpholine (Lot # ZA01212016) in approximately 25 mL of acetonitrile + 0.1% formic acid. Solubility was confirmed by visual inspection at a concentration of approximately 5000 μg/mL acetonitrile + 0.1% formic acid.
Solubility of 4-(3-(1-naphthylamino)propyl)morpholine (Lot # ZA01212016) has been demonstrated at a concentration of approximately 5,000 μg/mL in acetonitrile + 0.1% formic acid.
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