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EC number: 282-162-4 | CAS number: 84100-84-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Flammability
Administrative data
Link to relevant study record(s)
- Endpoint:
- flammable solids
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- UN Manual of Tests and Criteria: Test N.1 (Test method for readily combustible solids)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.10 (Flammability (Solids))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- BTS sample no. 122875
- Test procedure:
- burning rate test: preliminary screening test
- Burning time:
- 3 s
- Remarks on result:
- substance does not ignite and propagate combustion either by burning with flame or smouldering along 200 mm of the powder train within the 2 minutes test period
- Interpretation of results:
- not classified based on GHS criteria
- Conclusions:
- 2,3,3-trimethyl-3H-indole-5-carboxylic acid is classified as a not readily combustible solid when tested according to UN N.1 (Recommendations on the Transport of Dangerous Goods - Manual of Tests and Criteria (UN-MTC)) and EC A.10 (Guideline EC 440/2008).
- Executive summary:
A preliminary screening test was performed according to UN N.1 (Recommendations on the Transport of Dangerous Goods - Manual of Tests and Criteria (UN-MTC)) and EC A.10 (Guideline EC 440/2008) with 2,3,3-trimethyl-3H-indole-5-carboxylic acid to determine if propagation by burning with flame or smoldering occurs without wetted zone. The substance was formed into a powder train about 250 mm long by about 20 mm wide by about 10 mm high on a non-combustible, nonporous and low heat-conducting base plate.
2,3,3-trimethyl-3H-indole-5-carboxylic acid melted on approach of the burner flame. The test item burned for about 3 seconds after removal of the burner flame, than the test item stopped burning. A burning off of the complete powder train was not observed. The performance of the full test wasn't necessary.
Thus, 2,3,3-trimethyl-3H-indole-5-carboxylic acid is classified as a not readily combustible solid.
- Endpoint:
- self-heating substances / mixtures
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- UN Manual of Tests and Criteria: Test N.4 (Test method for self-heating substances)
- Qualifier:
- according to guideline
- Guideline:
- other: EU Method A.16 (Relative self-ignition temperature for solids)
- Version / remarks:
- Screening test, similar to Grewer oven test
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- BTS sample no. 122875
- Test procedure:
- other: Grewer oven test
- Result:
- negative outcome (no effect observed)
- Interpretation of results:
- not classified based on GHS criteria
- Conclusions:
- 2,3,3-trimethyl-3H-indole-5-carboxylic acid is not liable to self-heating.
- Executive summary:
The self-heating temperature of 2,3,3-trimethyl-3H-indole-5-carboxylic acid has been conducted according to UN N.4 (Recommendations on the Transport of Dangerous Goods - Manual of Tests and Criteria (UN-MTC). The test according to EC A.16 (Relative Self-Ignition Temperature) was used as a screening test. This test method is very similar to the Grewer oven test (VOl guideline 2263, part 1, 1990).
2,3,3-trimethyl-3H-indole-5-carboxylic acid was placed in a wire basket with 8 mL volume in an oven at room temperature. The oven was heated up with a rate of 0.5 K/min up to 420 °C. The temperature of the center of the sample and the temperature of an inert reference sample, which was placed in the oven too, were recorded.
In the temperature diagram no exothermic reactions are visible. After the test, the basket of the sample was nearly empty (little black residue at the bottom).
2,,3,3-trimethyl-3H-indole-5-carboxylic acid is not liable to self-heating.
- Endpoint:
- substances / mixtures which in contact with water emit flammable gases
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the organic substance does not contain metals or metalloids and hence, the classification procedure does not need to be applied
- Interpretation of results:
- not classified based on GHS criteria
- Conclusions:
- The substance does not ignite spontaneously with water and does not liberate gases in hazardous amounts.
- Executive summary:
The chemical structure of the substance contains no metals or metalloids. Testing according to UN-MTC procedure N.5 and EC A.12 is not necessary with reference to Appendix 6, chapter 5.3 of UN-MTC.
The substance does not ignite spontaneously with water and does not liberate gases in hazardous amounts.
- Endpoint:
- pyrophoric solids
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
- Interpretation of results:
- not classified based on GHS criteria
- Executive summary:
The test substance did not deliver indications of pyrophoric properties during the realization of other tests. Testing according to procedure N.2 and EC A.13 is not necessary.
The substance is classified with "no pyrophoric properties"
Referenceopen allclose all
The test item melted when approached by the burner flame. The test item stopped burning after 3 seconds after removal of the flame. A burning off of the complete powder train was not observed.
The performance of the full test wasn’t necessary.
After the test, the basket of the sample was nearly empty (little black residue at the bottom).
Description of key information
Flammability:
2,3,3-trimethyl-3H-indole-5-carboxylic acid is classified as a not readily combustible solid when tested according to UN N.1 and EC A.10.
Contact with water:
The chemical structure of the substance contains no metals or metalloids. Thus the substance does not ignite spontaneously with water and does not liberate gases in hazardous amounts.
Pyrophoric properties:
The test substance did not deliver indications of pyrophoric properties during the realization of other tests. So the substance is classified with "no pyrophoric properties".
Self-heating:
2,3,3-trimethyl-3H-indole-5-carboxylic acid is not liable to self-heating when tested according to UN N.4 (screening test according to EC A.16).
Key value for chemical safety assessment
- Flammability:
- not classified
Additional information
Justification for classification or non-classification
According to available data 2,3,3-trimethyl-3H-indole-5-carboxylic acid is not classified as flammable, self-heating or pyrophoric. Furthermore it does not ignite spontaneously with water and does not liberate gases in hazardous amounts.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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