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EC number: 267-234-5 | CAS number: 67827-72-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Endpoint summary
Administrative data
Description of key information
Acute Oral Toxicity:
In Acute oral toxicity ,LD50 value was predicted based on OECD QSAR toolbox for target substance 2-methoxy-5-nitroanilinium chloride (67827-72-9) was estimated to be 705.66 mg/kg bw,and for differentstudies available on the structurally similar read across substance 1-methoxy-2-methyl-4-nitrobenzene (99-53-6) was considered to be 390 mg/kg bw and for 3-nitrobenzoic acid (121-92-6) was considered to be 1820 mg/kg bw. All these studies concluded that the LD50 value is between 300-2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation, 2-methoxy-5-nitroanilinium chloride (67827-72-9) can be classified as category IV of acute oral toxicity.
Acute Inhalation Toxicity:
2-methoxy-5-nitroanilinium chloride (67827-72-9) has very low vapor pressure (1.63E-006 Pa.).So the potential for the generation of inhalable vapours is very low. Also the normal conditions of use of this substance will not result in aerosols, particles or droplets of an inhalable size, so exposure to humans via the inhalatory route will be highly unlikely and therefore the acute inhalation toxicity end point was considered for waiver.
Acute Dermal Toxicity:
In Acute dermal toxicity, LD50 value was predicted based on OECD QSAR toolbox for target substance 2-methoxy-5-nitroanilinium chloride (67827-72-9) was estimated to be 7228.03 mg/kg bw,and for differentstudies available on structurally similar read across substance 3'-Nitroacetophenone (121-89-1). All these studies concluded that the LD50 value is greater than 2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation, 2-methoxy-5-nitroanilinium chloride (67827-72-9) cannot be classified for acute dermal toxicity.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- (Q)SAR
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data is predicted using OECD QSAR toolbox version 3.3 and QMRF report has been attached
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Prediction was done by using OECD QSAR toolbox v3.3,2018
- GLP compliance:
- not specified
- Test type:
- other: estimated data
- Limit test:
- no
- Specific details on test material used for the study:
- - Name of test material: 2-methoxy-5-nitroanilinium chloride
- IUPAC name: 2-methoxy-5-nitroanilinium chloride
- Molecular formula: C7H9ClN2O3
- Molecular weight: 204.6121g/mol
- Smiles: Cl.COc1ccc(cc1N)[N+](=O)[O-]
- Inchl: 1S/C7H8N2O3.ClH/c1-12-7-3-2-5(9(10)11)4-6(7)8;/h2-4H,8H2,1H3;1H
- Substance type: Organic - Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- No data available
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data available
- Doses:
- 705.66 mg/kg bw
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
- Preliminary study:
- No data available
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 705.66 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality was observed
- Mortality:
- No data available
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The LD50 value was estimated to be 705.66 mg/kg bw,when male Sprague-Dawley rats were orally exposed with 2-methoxy-5-nitroanilinium chloride (67827-72-9).
- Executive summary:
In a prediction done by SSS (2018) using the OECD QSAR toolbox with log kow as the primary descriptor, the acute oral toxicity was estimated for 2-methoxy-5-nitroanilinium chloride (67827-72-9).The LD50 was estimated to be 705.66 mg/kg bw,when male Sprague-Dawley rats were orally exposed with 2-methoxy-5-nitroanilinium chloride (67827-72-9).
Reference
The
prediction was based on dataset comprised from the following
descriptors: LD50
Estimation method: Takes average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
((((((((((((("a"
or "b" or "c" )
and ("d"
and (
not "e")
)
)
and ("f"
and (
not "g")
)
)
and "h" )
and ("i"
and (
not "j")
)
)
and "k" )
and ("l"
and (
not "m")
)
)
and ("n"
and (
not "o")
)
)
and ("p"
and (
not "q")
)
)
and ("r"
and (
not "s")
)
)
and ("t"
and (
not "u")
)
)
and ("v"
and (
not "w")
)
)
and ("x"
and "y" )
)
Domain
logical expression index: "a"
Referential
boundary: The
target chemical should be classified as Radical AND Radical >> Radical
mechanism via ROS formation (indirect) AND Radical >> Radical mechanism
via ROS formation (indirect) >> Nitrophenols, Nitrophenyl Ethers and
Nitrobenzoic Acids AND SN1 AND SN1 >> Nucleophilic attack after
reduction and nitrenium ion formation AND SN1 >> Nucleophilic attack
after reduction and nitrenium ion formation >> Nitrophenols, Nitrophenyl
Ethers and Nitrobenzoic Acids by DNA binding by OASIS v.1.3
Domain
logical expression index: "b"
Referential
boundary: The
target chemical should be classified as SN1 AND SN1 >> Nitrenium Ion
formation AND SN1 >> Nitrenium Ion formation >> Aromatic nitro by DNA
binding by OECD
Domain
logical expression index: "c"
Referential
boundary: The
target chemical should be classified as Strong binder, NH2 group by
Estrogen Receptor Binding
Domain
logical expression index: "d"
Referential
boundary: The
target chemical should be classified as Strong binder, NH2 group by
Estrogen Receptor Binding
Domain
logical expression index: "e"
Referential
boundary: The
target chemical should be classified as Moderate binder, NH2 group OR
Moderate binder, OH grooup OR Non binder, impaired OH or NH2 group OR
Non binder, MW>500 OR Non binder, non cyclic structure OR Non binder,
without OH or NH2 group OR Strong binder, OH group OR Very strong
binder, OH group OR Weak binder, NH2 group OR Weak binder, OH group by
Estrogen Receptor Binding
Domain
logical expression index: "f"
Referential
boundary: The
target chemical should be classified as No alert found by Protein
binding by OECD
Domain
logical expression index: "g"
Referential
boundary: The
target chemical should be classified as Acylation OR Acylation >> Direct
Acylation Involving a Leaving group OR Acylation >> Direct Acylation
Involving a Leaving group >> Acetates OR SN2 OR SN2 >> SN2 reaction at
sp3 carbon atom OR SN2 >> SN2 reaction at sp3 carbon atom >> Allyl
acetates and related chemicals OR SNAr OR SNAr >> Nucleophilic aromatic
substitution OR SNAr >> Nucleophilic aromatic substitution >> Activated
halo-benzenes by Protein binding by OECD
Domain
logical expression index: "h"
Referential
boundary: The
target chemical should be classified as Bioavailable by Lipinski Rule
Oasis ONLY
Domain
logical expression index: "i"
Referential
boundary: The
target chemical should be classified as Halogens AND Non-Metals by
Groups of elements
Domain
logical expression index: "j"
Referential
boundary: The
target chemical should be classified as Alkali Earth by Groups of
elements
Domain
logical expression index: "k"
Similarity
boundary:Target:
COc1ccc(N(=O)=O)cc1N{+}.Cl{-}
Threshold=20%,
Dice(Atom centered fragments)
Atom type; Count H attached; Hybridization
Domain
logical expression index: "l"
Referential
boundary: The
target chemical should be classified as Anilines (Hemolytic anemia with
methemoglobinemia) Rank A AND Anilines (Hepatotoxicity) Rank C by
Repeated dose (HESS)
Domain
logical expression index: "m"
Referential
boundary: The
target chemical should be classified as
4,4'-Methylenedianilines/benzidines (Hepatobiliary toxicity) Rank B OR
Aliphatic amines (Mucous membrane irritation) Rank C by Repeated dose
(HESS)
Domain
logical expression index: "n"
Referential
boundary: The
target chemical should be classified as Anilines (Hemolytic anemia with
methemoglobinemia) Rank A AND Anilines (Hepatotoxicity) Rank C by
Repeated dose (HESS)
Domain
logical expression index: "o"
Referential
boundary: The
target chemical should be classified as Thiocarbamates/Sulfides
(Hepatotoxicity) No rank by Repeated dose (HESS)
Domain
logical expression index: "p"
Referential
boundary: The
target chemical should be classified as Aliphatic Amine, primary AND
Ether AND Nitrobenzene AND Overlapping groups by Organic Functional
groups (nested)
Domain
logical expression index: "q"
Referential
boundary: The
target chemical should be classified as Alkyl halide by Organic
Functional groups (nested)
Domain
logical expression index: "r"
Referential
boundary: The
target chemical should be classified as Aliphatic Amine, primary AND
Ether AND Nitrobenzene AND Overlapping groups by Organic Functional
groups (nested)
Domain
logical expression index: "s"
Referential
boundary: The
target chemical should be classified as Alkoxy by Organic Functional
groups (nested)
Domain
logical expression index: "t"
Referential
boundary: The
target chemical should be classified as Aliphatic Amine, primary AND
Ether AND Nitrobenzene AND Overlapping groups by Organic Functional
groups (nested)
Domain
logical expression index: "u"
Referential
boundary: The
target chemical should be classified as Sulfate by Organic Functional
groups (nested)
Domain
logical expression index: "v"
Referential
boundary: The
target chemical should be classified as Aliphatic Amine, primary AND
Ether AND Nitrobenzene AND Overlapping groups by Organic Functional
groups (nested)
Domain
logical expression index: "w"
Referential
boundary: The
target chemical should be classified as Aryl halide OR Biphenyl by
Organic Functional groups (nested)
Domain
logical expression index: "x"
Parametric
boundary:The
target chemical should have a value of log Kow which is >= -2.8
Domain
logical expression index: "y"
Parametric
boundary:The
target chemical should have a value of log Kow which is <= 0.553
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 705.66 mg/kg bw
- Quality of whole database:
- Data is Klimisch 2 and from QSAR toolbox 3.3
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Data waiving:
- other justification
- Justification for data waiving:
- other:
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Quality of whole database:
- Waiver
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data is predicted using OECD QSAR toolbox version 3.3 and QMRF report has been attached
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Prediction was done by using OECD QSAR toolbox v3.3,2018
- GLP compliance:
- not specified
- Test type:
- other: estimated data
- Limit test:
- no
- Specific details on test material used for the study:
- - Name of test material: 2-methoxy-5-nitroanilinium chloride
- IUPAC name: 2-methoxy-5-nitroanilinium chloride
- Molecular formula: C7H9ClN2O3
- Molecular weight: 204.6121g/mol
- Smiles: Cl.COc1ccc(cc1N)[N+](=O)[O-]
- Inchl: 1S/C7H8N2O3.ClH/c1-12-7-3-2-5(9(10)11)4-6(7)8;/h2-4H,8H2,1H3;1H
- Substance type: Organic
- Physical State: Solid - Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data available
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Details on dermal exposure:
- no data available
- Duration of exposure:
- 24 hours
- Doses:
- 3128.45 mg/kg bw
- No. of animals per sex per dose:
- no data available
- Control animals:
- not specified
- Details on study design:
- no data available
- Statistics:
- no data available
- Preliminary study:
- no data available
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 3 128.45 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% Mortality was observed
- Mortality:
- no data available
- Clinical signs:
- other: no data available
- Gross pathology:
- no data available
- Other findings:
- no data available
- Interpretation of results:
- other: not classified
- Conclusions:
- The LD50 value was estimated to be 3128.45 mg/kg bw,when new Zealand white rabbits were occlusively exposed with 2-methoxy-5-nitroanilinium chloride (67827-72-9) by dermal application for 24 hours.
- Executive summary:
In a prediction done by SSS (2018) using the OECD QSAR toolbox with log kow as the primary descriptor, the acute dermal toxicity was estimated for 2-methoxy-5-nitroanilinium chloride (67827-72-9).The LD50 was estimated to be 3128.45 mg/kg bw,when new Zealand white rabbits were occlusively exposed with 2-methoxy-5-nitroanilinium chloride (67827-72-9)by dermal application for 24 hours.
Reference
The
prediction was based on dataset comprised from the following
descriptors: LD50
Estimation method: Takes average value from the 6 nearest neighbours
Domain logical expression:Result: In Domain
(((((("a"
or "b" or "c" )
and ("d"
and (
not "e")
)
)
and ("f"
and (
not "g")
)
)
and ("h"
and (
not "i")
)
)
and ("j"
and (
not "k")
)
)
and ("l"
and "m" )
)
Domain
logical expression index: "a"
Referential
boundary: The
target chemical should be classified as Radical AND Radical >> Radical
mechanism via ROS formation (indirect) AND Radical >> Radical mechanism
via ROS formation (indirect) >> Nitrophenols, Nitrophenyl Ethers and
Nitrobenzoic Acids AND SN1 AND SN1 >> Nucleophilic attack after
reduction and nitrenium ion formation AND SN1 >> Nucleophilic attack
after reduction and nitrenium ion formation >> Nitrophenols, Nitrophenyl
Ethers and Nitrobenzoic Acids by DNA binding by OASIS v.1.3
Domain
logical expression index: "b"
Referential
boundary: The
target chemical should be classified as SN1 AND SN1 >> Nitrenium Ion
formation AND SN1 >> Nitrenium Ion formation >> Aromatic nitro by DNA
binding by OECD
Domain
logical expression index: "c"
Referential
boundary: The
target chemical should be classified as Strong binder, NH2 group by
Estrogen Receptor Binding
Domain
logical expression index: "d"
Referential
boundary: The
target chemical should be classified as Not possible to classify
according to these rules by DPRA Cysteine peptide depletion
Domain
logical expression index: "e"
Referential
boundary: The
target chemical should be classified as High reactive OR High reactive
>> Activated haloarenes by DPRA Cysteine peptide depletion
Domain
logical expression index: "f"
Referential
boundary: The
target chemical should be classified as Strong binder, NH2 group by
Estrogen Receptor Binding
Domain
logical expression index: "g"
Referential
boundary: The
target chemical should be classified as Moderate binder, OH grooup by
Estrogen Receptor Binding
Domain
logical expression index: "h"
Referential
boundary: The
target chemical should be classified as Anilines (Hemolytic anemia with
methemoglobinemia) Rank A AND Anilines (Hepatotoxicity) Rank C by
Repeated dose (HESS)
Domain
logical expression index: "i"
Referential
boundary: The
target chemical should be classified as Thiocarbamates/Sulfides
(Hepatotoxicity) No rank by Repeated dose (HESS)
Domain
logical expression index: "j"
Referential
boundary: The
target chemical should be classified as Anilines (Hemolytic anemia with
methemoglobinemia) Rank A AND Anilines (Hepatotoxicity) Rank C by
Repeated dose (HESS)
Domain
logical expression index: "k"
Referential
boundary: The
target chemical should be classified as Aliphatic amines (Mucous
membrane irritation) Rank C by Repeated dose (HESS)
Domain
logical expression index: "l"
Parametric
boundary:The
target chemical should have a value of OVERALL OH rate constant which is
>= 1.22E-013 cm3/molecule-sec
Domain
logical expression index: "m"
Parametric
boundary:The
target chemical should have a value of OVERALL OH rate constant which is
<= 5E-011 cm3/molecule-sec
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Dose descriptor:
- LD50
- Value:
- 3 128.45 mg/kg bw
- Quality of whole database:
- Data is Klimisch 2 and from QSAR toolbox 3.3
Additional information
Acute Oral Toxicity:
In different studies, 2-methoxy-5-nitroanilinium chloride (67827-72-9) has been investigated for acute oral toxicity to a greater or lesser extent. Often the studies are based on in vivo experiments and estimated data in rodents, i.e. most commonly in rats for 2-methoxy-5-nitroanilinium chloride (67827-72-9) along with the study available on the structurally similar read across substance 1-methoxy-2-methyl-4-nitrobenzene (99-53-6) and for 3-nitrobenzoic acid (121-92-6). The predicted data using the OECD QSAR toolbox has also been compared with the experimental studies. The studies are summarized as below –
In a prediction done by SSS (2018) using the OECD QSAR toolbox with log kow as the primary descriptor, the acute oral toxicity was estimated for 2-methoxy-5-nitroanilinium chloride (67827-72-9).The LD50 was estimated to be 705.66 mg/kg bw,when male Sprague-Dawley rats were orally exposed with 2-methoxy-5-nitroanilinium chloride (67827-72-9).
In experimental study conducted by U.S. National Library of Medicine (Chemidplus Database,U.S. National Library of Medicine,2017) and RTECS (RTECS (registry of toxic effect of chemical substance database), 2017) for the structurally similar read across substance 1-methoxy-2-methyl-4-nitrobenzene (99-53-6). Acute oral toxicity study was done in mouse using test material 1-methoxy-2-methyl-4-nitrobenzene (99-53-6).50% mortality was observed at dose 390 mg/kg bw. Hence,LD50 value was considered to be 390 mg/kg bw,when mouse was treated with 1-methoxy-2-methyl-4-nitrobenzene (99-53-6) orally.
Also these results are further supported by MAK Collection for Occupational Health and Safety (3-Nitrobenzoesäure [MAK Value Documentation in German Language, 2015] The MAK Collection for Occupational Health and Safety, 1–15,2015) and ENVIRONMENTAL HEALTH RESEARCH AND TESTING, INC. (National Toxicology Program National Institute of Environmental Health Sciences; .June, 1989) for the structurally similar read across substance 3-nitrobenzoic acid (121-92-6). An acute oral test was conducted on female wistar rats to determine its LD50.During the test, the animals were exposed to the chemical at concentration f1820 mg/kg body weight. The treated rats had developed symptoms of over-excitability, immobility, motor disturbances or aggressiveness occurred as symptoms of poisoning. No conspicuous findings were found in macroscopic examinations.Thus on the basis of observed effects, the LD50 of test chemical 3-nitrobenzoic acid (CAS No: 121-92-6) was estimated to be 1820 mg/kg body weight in female wistar rats.
Thus, based on the above studies on 2-methoxy-5-nitroanilinium chloride (67827-72-9) and it’s structurally similar read across substances 1-methoxy-2-methyl-4-nitrobenzene (99-53-6) and 3-nitrobenzoic acid (121-92-6), it can be concluded that LD50 value is between 300-2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation, 2-methoxy-5-nitroanilinium chloride (67827-72-9) can be classified as category IV of acute oral toxicity.
Acute Inhalation Toxicity:
2-methoxy-5-nitroanilinium chloride (67827-72-9) has very low vapor pressure (1.63E-006 Pa.).So the potential for the generation of inhalable vapours is very low. Also the normal conditions of use of this substance will not result in aerosols, particles or droplets of an inhalable size, so exposure to humans via the inhalatory route will be highly unlikely and therefore the acute inhalation toxicity end point was considered for waiver.
Acute Dermal Toxicity:
In different studies, 2-methoxy-5-nitroanilinium chloride (67827-72-9) has been investigated for acute dermal toxicity to a greater or lesser extent. Often the studies are based on in vivo experiments and estimated data in rodents, i.e. most commonly in rabbits for 2-methoxy-5-nitroanilinium chloride (67827-72-9) along with the study available on structurally similar read across substance substance 3'-Nitroacetophenone (121-89-1).The predicted data using the OECD QSAR toolbox has also been compared with the experimental studies. The studies are summarized as below –
In a prediction done by SSS (2018) using the OECD QSAR toolbox with log kow as the primary descriptor, the acute dermal toxicity was estimated for 2-methoxy-5-nitroanilinium chloride (67827-72-9).The LD50 was estimated to be 3128.45 mg/kg bw,when new Zealand white rabbits were occlusively exposed with 2-methoxy-5-nitroanilinium chloride (67827-72-9)by dermal application for 24 hours.
The above study was further supported by U.S. National Library of Medicine (Chemidplus Database,U.S. National Library of Medicine,2017) andRTECS(RTECS (registry of toxic effect of chemical substance database), 2017) for thestructurally similar read across substance substance 3'-Nitroacetophenone (121-89-1).In Acute dermal toxicity study, rabbits were treated with 3'-Nitroacetophenone (121-89-1) in the concentration of 3000 mg/kg bw by dermal application. 50% mortality was observed in treated rabbits at 3000 mg/kg bw. Therefore,LD50 was considered to be 3000 mg/kg bw,when rabbits were treated with 3'-Nitroacetophenone (121-89-1) by dermal application.
Thus, based on the above studies on 2-methoxy-5-nitroanilinium chloride (67827-72-9) and it’s structurally similar read across substances, it can be concluded that LD50 value is greater than 2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation, 2-methoxy-5-nitroanilinium chloride (67827-72-9) cannot be classified for acute dermal toxicity.
Justification for classification or non-classification
Based on the above studies on 2-methoxy-5-nitroanilinium chloride (67827-72-9) and it’s structurally similar read across substance 1-methoxy-2-methyl-4-nitrobenzene (99-53-6); 3-nitrobenzoic acid (121-92-6) and 3'-Nitroacetophenone (121-89-1), it can be concluded that LD50 value is between 300-2000 mg/kg bw for acute oral toxicity and greater than 2000 mg/kg bw for acute dermal toxicity. Thus, comparing this value with the criteria of CLP regulation, 2-methoxy-5-nitroanilinium chloride (67827-72-9) can be classified as category IV for acute oral toxicity and cannot be classified for acute dermal toxicity. For Acute inhalation toxicity wavier was added so, not possible to classify.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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