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Diss Factsheets
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EC number: 207-997-3 | CAS number: 504-63-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Health surveillance data
Administrative data
- Endpoint:
- health surveillance data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
- Study type:
- other: study with volunteers
- Endpoint addressed:
- skin irritation / corrosion
- Principles of method if other than guideline:
- Repetitive epidermal contact of the test substance to induce primary or cummulative irritation and/or allergic contact sensitization was studied.
- GLP compliance:
- yes
Test material
- Reference substance name:
- Propane-1,3-diol
- EC Number:
- 207-997-3
- EC Name:
- Propane-1,3-diol
- Cas Number:
- 504-63-2
- Molecular formula:
- C3H8O2
- IUPAC Name:
- propane-1,3-diol
- Details on test material:
- - Purity: 99.95%
Constituent 1
Results and discussion
- Results:
- The test substance did not indicate a clinically significant potential for dermal irritation.
Any other information on results incl. tables
The vehicle controls were negative for skin reactions throughout the test interval.
25% at pH 7: Two subjects exhibited a barely perceptible response 24 hours post-challenge application. These sites were negative at the final observation. The transitory responses were considered clinically insignificant.
50% at pH 7: Three subjects exhibited a barely perceptible or mild response 24 hours post-challenge application. These sites were negative at the final observation. A different subject exhibited a mild to barely perceptible response 24 and 72 hours post challenge. No other dermal sequelae was observed. These weak, transitory responses were considered clinically insignificant.
75% at pH7: Six subjects exhibited a barely perceptible response 24 and possibly 72 hours post challenge. However, most of these sites were negative at final observation. No other dermal sequelae was observed. These weak, transitory responses were considered clinically insignificant.
75% at pH 4: Six subjects exhibited a mild and or barely perceptible response post-challenge application. No other dermal sequelae was observed. These weak, transitory responses were considered clinically insignificant.
75% at pH 9: Six subjects exhibited a mild and or barely perceptible response post-challenge application. No other dermal sequelae was observed. These weak, transitory responses were considered clinically insignificant.
Applicant's summary and conclusion
- Conclusions:
- The test substance did not indicate a clinically significant potential for dermal irritation or allergic contact sensitization.
- Executive summary:
1,3-Propanediol was tested at various concentrations and pHs to determine its potential to cause irritation or delayed contact hypersensitivity in humans. Under the conditions of the study, the test substance did not indicate a clinically significant potential for dermal irritation or allergic contact sensitization.
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