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Diss Factsheets
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EC number: 207-997-3 | CAS number: 504-63-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- ACC PDO panel assigned reliability of 1. PDO from chemical process.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Qualifier:
- according to guideline
- Guideline:
- other: EPA, EG-9 (1982)
- GLP compliance:
- yes
- Remarks:
- GLP, except for the test substance that was not characterized in compliance with GLP. This does not impact the validity of the study.
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations:
Nominal mg/L : 0 (control), 750, 1250, 2500, 5000, 10000. One sample plus a back-up sample of each test solution was received on day 0 and day 4 from each replicate test chamber at all nominal test concentrations including the control.
- Sample storage conditions before analysis: All samples were analyzed immediately on the day of receipt or held refrigerated until analysis. - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: Test solutions were prepared by direct addition of the test substance to dilution water. Nominal concentrations were not adjusted for purity. Nominal test solutions of 750, 1250, 2500, 5000, and 10000 mg/L were prepared by pipetting the test material into separate weigh boats and transferring the material to individual beakers. The contents of each beaker were then poured into the appropriate 26-L stainless steel tank containing Haskell Laboratory Well Water for a final test solution volume of 15-L. All test solutions, including the water control, were stirred for 30 minutes prior to use.
- Evidence of undissolved material (e.g. precipitate, surface film, etc): Test substance solutions were clear and colorless with no insoluble material present. - Test organisms (species):
- Pimephales promelas
- Details on test organisms:
- TEST ORGANISM
- Common name: Fathead minnow
- Source: Haskell Laboratory bred
- Length at study conclusion: Mean: 3.3 cm (water controls)
- Weight at study conclusion: Mean: 0.52 g (water controls)
- Feeding during test : No
ACCLIMATION
- Acclimation period: 7 days.
- Acclimation conditions (same as test or not): The fish were fed until 48 hours preceding the test, and the mean temperature was 24.9°C.
- Type and amount of food: Freshly-hatched, live brine shrimp (Aquarium Products)/AquaMax Starter Fingerling 300 5D03 (PMI Nutrition International, Inc.) and frozen brine shrimp (Aquarium Products.)
- Feeding frequency: Twice daily on weekdays and once daily on weekends and holidays.
- Health during acclimation (any mortality observed): No mortality observed during 48 hours prior to use for testing. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Hardness:
- EDTA Hardness of the dilution water control at 0h : 117 mg/L CaCO3.
Total Alkalinity of the dilution water control at 0h : 48 mg/L CaCO3. - Test temperature:
- Mean for each test concentration was 22°C (21.9-22.0°C)
- pH:
- pH was measured for all test concentrations at 24h intervals.
At 0 hours: 7.6 - 7.7
At 24 hours: 7.4 - 7.5
At 48 hours: 7.5
At 72 hours: 7.4
At 96 hours: 7.4 - 7.5 - Dissolved oxygen:
- DO (mg/L) was measured for all test concentrations at 24 hour intervals.
At 0 hours: 8.7
At 24 hours: 6.8 - 7.0
At 48 hours: 6.2 - 6.5
At 72 hours: 6.0 - 6.2
At 96 hours: 5.4 - 6.0 - Nominal and measured concentrations:
- Nominal concentrations (mg/L): 0 (water control), 750, 1250, 2500, 5000, 10000
Mean measured concentration: ND (none detected, limit of detection was 0.67 mg/L), 720, 1230, 2330, 4780, 9720 - Details on test conditions:
- TEST SYSTEM
- Test vessel: Stainless steel aquaria [30 (length) x 30 (width) x 30 (height) cm] which held approximately 15 L of test solution (26 L maximum volume). Each vessel was covered with a glass plate to prevent fish from escaping.
- No. of organisms per vessel: 10 fish/vessel
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
- Biomass loading rate: Loading in the water control was 0.35 g/L at test conclusion.
- Other: Random numbers were used to assign test concentrations to the test chambers and position of test concentrations in the water bath.
OTHER TEST CONDITIONS
- Adjustment of pH: Not conducted
- Photoperiod: 16 hours light (approx. 270-438 Lux) and 8 hours darkness including 30 minutes of transitional light (32-139 Lux) preceding and following the 16-hour light interval.
EFFECT PARAMETERS MEASURED: Mortality and behavioral observations were made at test start, every 24 hours thereafter, and at test end.
- Range finding study
- Test concentrations: A static rangefinding study with 5 fish per concentration was conducted using a dilution water control and nominal concentrations of 10,000, 20,000 and 30,000 mg/L.
- Results used to determine the conditions for the definitive study: At the end of 96 hours, the respective mortality values were 0, 0, and 0%. Test substance solutions were clear and colorless with no insoluble material present during the test. Because no mortalities were observed during the rangefinding study, a limit test was started using a dilution water control (1 replicate of 10 fish) and a nominal test concentration of 10,000 mg/L (3 replicates, 10 fish/replicate). Test substance solutions were clear and colorless with no insoluble material present. The limit test was terminated due to mortalities (10%) in the limit test concentration. All the mortalities occurred in 1 of the 3 replicate test chambers. Due to the mortalities at the limit concentration, a dose-response study was conducted. - Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 9 720 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Details on results:
- No mortality or sublethal effects were seen in any of the test concentrations or the dilution water control fish during the entire test.
Dilution water quality was acceptable. All chemical and physical parameters for the test were within expected ranges.
At test conclusion, fish from the water control ranged from 3.0 to 3.7 cm in standard length and 0.40 to 0.63 in wet weight, blotted dry. The standard length of the longest fish was not more than twice the length of the shortest fish in the control. - Validity criteria fulfilled:
- yes
- Conclusions:
- 96-hr LC50 to fathead minnow is > 9720 mg/L
- Executive summary:
1,3 -Propanediol was assessed for acute toxicity to unfed juvenile fathead minnow, Pimephales promelas, in an unaerated, static, 96-hour test using measured concentrations of 0, 720, 1230, 2330, 4780, 9720 mg/L in accordance with OECD Guideline 203. No mortality or sublethal effects were seen in any of the test concentrations or the dilution water control fish during the entire test. The 96-hour LC50 based on mean, measured concentrations was > 9720 mg/L.
Reference
Description of key information
96h LC50 for freshwater fish: >9720 mg/L
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 9 720 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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