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EC number: 931-276-9 | CAS number: 114959-46-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1991-08-14 to 1991-08-29
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Date of inspection 1990-05-14
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Benzoic acid, 2-hydroxy-, mono-C14-18-alkyl derivs., calcium salts (2:1)
- EC Number:
- 931-276-9
- Cas Number:
- 114959-46-5
- Molecular formula:
- See information in Section 1.2.
- IUPAC Name:
- Benzoic acid, 2-hydroxy-, mono-C14-18-alkyl derivs., calcium salts (2:1)
- Details on test material:
- - Name of test material (as cited in study report): [CAS Number 114959-46-5]
- Physical state: Clear brown viscous liquid
- Lot/batch No.: 191 (Stanlow); DSP4767/91
- Toxicology reference number: ST91/247
- Stability under test conditions: Stable for the duration of the study under the test conditions employed
- Storage condition of test material: In the dark at ambient temperature under nitrogen
- Date received: 08 August 1991
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River UK Ltd
- Age at study initiation: 8-9 weeks
- Weight at study initiation: 195-219 g (males); 137-155 g (females)
- Fasting period before study: Overnight
- Housing: Single sex groups of up to 5 rats to a cage during quarantine; Single sex groups of up to 3 rats to a cage for at least five days prior to dosing in cages with stainless steel wire-mesh walls floors and tops. Each cage measured 33 cm x 22 cm x 16 cm. Paper-lined trays for excreta were placed beneath each cage and changed three times weekly.
- Diet (e.g. ad libitum): Pelleted diet (LAD 1, Special Diets Services Ltd) ad libitum
- Water (e.g. ad libitum): Water from the public supply ad libitum
- Acclimation period: Minimum of four days quarantine in non-barried animal room with access restricted to essential personnel plus five days acclimation prior to dosing
ENVIRONMENTAL CONDITIONS
- Temperature: 19-23 degrees Centigrade with no excursions considered to have influenced the experimental outcome
- Humidity: 30-70 % with no excursions considered to have influenced the experimental outcome
- Photoperiod: 12 hour day and 12 hour night provided by automatically controlled fluorescent lighting
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- On the day before dosing, the dorsal fur was removed from the animals using electric clippers. Any rat showing signs of damage or irritation of the dorsum were replaced. On Day 1 the animals were weighed and a single dose of the undiluted test material was applied to the skin. The test material was held in place with a gauze dressing (approximately 6 x 8 cm) covered with waterproof adhesive tape. The rats were then individually housed. Following exposure the dressings were removed, the skin washed with warm dilute detergent solution, dried and the animals returned to group housing.
- Duration of exposure:
- 24 hours
- Doses:
- Single dose of 2000 mg/kg administered at a dose volume of 1.90 mL/kg
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- no
- Details on study design:
- Animals assigned to the study were identified by cage labels displaying the animal numbers, experiment number, sex and test material and by ear-notches denoting the animal number.
A detailed clinical examination was made six times on the day of dosing (Day 1) and twice daily thereafter for the remainder of the 14 day observation period. The initial (Day 1), Day 8 and Day 15 bodyweights were recorded and changes in bodyweight calculated.
All animals were subject to necropsy on Day 15. Animals were killed by an intraperitoneal injection of sodium pentabarbitone. External surfaces and orifices were checked and the cranial, thoracic and abdominal cavities and viscera were examined. Any gross pathological changes were recorded. - Statistics:
- No data
Results and discussion
- Preliminary study:
- No data
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No animals died
- Clinical signs:
- other: Female rats showed anogenital fur staining (yellow) from Day 2. Recovery was complete by Day 4. Sites of application of the test material were stained brown and, in male rats, had developed erythema by Day 2. The treated skin was overtly normal from Day 4
- Gross pathology:
- No macroscopic changes were apparent during necropsy on Day 15.
- Other findings:
- No data
Applicant's summary and conclusion
- Conclusions:
- The acute dermal LD50 of the test material in rats was greater than 2000 mg/kg
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