Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 251-717-2 | CAS number: 33885-51-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Degradation
Air: Based on estimation with the QSAR model Aopwin the substance undergoes in air rapid degradation after reaction with hydroxyl radicals and ozone. The DT50-value after reaction with hydroxyl radicals is 1.108 hours (rate constant is 115.88 E-12 cm3/molecule-sec). For reaction with Ozone, the atmospheric half -lifetime is 0.027 days (rate constant is 43 E-17 cm3/molecule-sec). Based on these half-lives, the substance will not reach the stratosphere and is therefore not considered to be a long-range transported chemical in air. The substance does not have an ozone depletion potential because it does not contain halogens and does not have the potential to reach the stratosphere (EU CLP, EC no 1272/2008 and its amendments).
Water: Examination of the substance's chemical structure shows that it contains no hydrolysable groups (such as e.g. ester, carbamates, epoxides, halomethanes, acylhalides (see Hydrowin, EpiSuite for all hydrolysable groups)). The half-life at 25 °C is > 1 year.
Biotic degradation of the substance was determined by the Closed Bottle test according to OECD TG 301D under GLP. The substance was degraded by 14% at day 28. In the prolonged Closed Bottle test, the test item was biodegraded by 72 % at day 60 (enhanced biodegradability testing). The substance should be regarded as not readily biodegradable according to this test, but is not expected to be persistent in the environment based on the 60 and 70 day results.
Bioaccumulation in aquatic and terrestrial species is based on the available information (log Kow and calculated BCF values). The BCFs for aquatic and terrestrial organisms were calculated using QSARs of Veith et al. (1979) and Jager (1998), both incorporated in the EUSES model, and yielded values of 902 and 240 L/kg ww, respectively, using a log Kow of 4.3.
Transport and distribution
The adsorption potential of the substance was determined in a study according to OECD TG 121 (HPLC method). Under the conditions of the test, the log Koc of the substance was determined at 3.19 (equivalent Koc = 1.5E3 L/kg) based on the main peak (98 area%). Based on this value the substance has potential for adsorption to solid surfaces and soil.
A Henry's law constant of 6.52 Pa·m³/mol (at 12°C) was calculated in EUSES (Vapour pressure 4.71 Pa (25°C), 178.75 g/mol molecular weight and 61.7 mg/l water solubility (25°C). Based on this value the substance has potential to partition from water to air under environmental conditions (12°C).
Based on Level III environmental distribution modelling using EPISUITE (assuming equal and continuous releases to air, water and soil) using the CAS number 33885-51-7 and the measured physico-chemical parameters (water solubility and log Kow) as input, it is estimated that the majority of the substance released to the environment will partition mainly into soil (79.8%) and water (19.9%) with small amounts to air (0.0698%) and sediment (0.194%).
The SimpleTreat model, which is incorporated in EUSES simulates the distribution of the substance in a Sewage Treatment Plant based on vapour pressure, water solubility, log Koc and ready biodegradability. Model calculations show that 0% of the substance will be degraded, and that 75.5%, 15.7%, and 8.8% will partition to water, sludge and air, respectively.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.