Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 813-789-9 | CAS number: 152873-67-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- July 18, 2018 - November 09, 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Version / remarks:
- OECD No. 301 F, 1992
- Deviations:
- no
- Principles of method if other than guideline:
- This study was conducted in compliance with the most recent edition of:
The OECD Principles of Good Laboratory Practice
German Chemicals Act (ChemG), Annex 1
Directive 2004/10/EC
These requirements are accepted by regulatory authorities throughout the European Community, the United States of America (FDA and EPA) and Japan (MHLW, MAFF and METI) on the basis of intergovernmental agreements. - GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- (2Z)-2-fluoro-3-(morpholin-4-yl)prop-2-enal
- EC Number:
- 813-789-9
- Cas Number:
- 152873-67-1
- Molecular formula:
- C7H10FNO2
- IUPAC Name:
- (2Z)-2-fluoro-3-(morpholin-4-yl)prop-2-enal
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- Name: Fluormorpholinylacrylaldehyd
Synonym: FMA / (2Z)-2-Fluor-3-(morpholin-4-yl)acrylaldehyd
Batch No.: BXR82PT
CAS-Nr.: 152873-67-1
Purity: 86.7%
Aggregate State at Room Temperature: Solid
Color: Orange-brownish
Molecular Formula / Molecular Weight: C7H10FNO2 / 159.16 g/mol
Theoretical Oxygen Demand: ThODNH4: 1.508 mg oxygen per mg test item
ThODNO3: 1.910 mg oxygen per mg test item
Retest date: November 01, 2018
Storage Conditions at Test Facility: After receipt at the test facility for 8 days at 4 ± 4 °C until storage recommendations were provided; thereafter at 20 +- 5°C in the dar
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic (adaptation not specified)
- Details on inoculum:
- Aerobic activated sludge, microorganisms from a domestic waste water treatment plant was supplied by the sewage treatment plant Rossdorf, Germany.
The aerobic activated sludge used for this study was deposited for 15 min, washed by centrifugation and the supernatant liquid phase was decanted. The solid material was re-suspended in test water and centrifuged again. This procedure was done three times. An aliquot of the final sludge suspension was weighed, dried and the ratio of wet sludge to its dry weight was determined. Based on this ratio, calculated aliquots of washed sludge suspension, corresponding to 3.5 g dry material per litre were mixed with test water (see 6.5) and aerated overnight. This suspension was used for the experiment. - Duration of test (contact time):
- >= 28 d
Initial test substance concentration
- Initial conc.:
- 100 mg/L
- Based on:
- test mat.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- The test item Fluormorpholinylacrylaldehyd was investigated for its ready biodegradability in a manometric respirometry test over a period of 28 days. The biodegradation was followed by the oxygen uptake of the microorganisms during exposure. As a reference item sodium benzoate was tested simultaneously under the same conditions as the test item, and functioned as a procedure control.
Endpoints:
Degradation rate of test item calculated by the oxygen consumption of the aerobic activated sludge microorganisms after 28 days of incubation.
Test Item Loading Rate (initial concentration in medium C0): 103.5 mg/L corresponding to an oxygen demand of about 156.1 mg/L (ThODNH4) and 197.7 mg/L (ThODN03)
Reference Item:
Sodium Benzoate
Reference Item Loading Rate:
100.4 mg/L corresponding to an oxygen demand of about 167.3 mg/L (ThODNH4)
Test Conditions: 22°C ± 1°C, darkness
Type and Size:
Manometric Test System with test flasks containing a volume of approximately 500 mL.
Apparatus:
BSB/BOD-Sensor-System, Aqualytic Dortmund, Germany
Principle:
The test flasks prepared according paragraph 6.6 were incubated at 22°C * 1°C. The pressure decrease
in the reaction vessels was measured over complete experimental phase of 28 days using the BSB/BO
D-Sensor-System, Aqualytic Dortmund, Germany. The test flasks were closed gas-tight by a measuring
head. Potassium hydroxide solution (45%) was used for trapping the produced carbon dioxide. The amo
unt of O2 consumed by the activated sludge was calculated from the decrease of pressure in the reaction
vessel.
Preparation of Test Flasks:
The amounts of test item and reference item were directly weighed into the test flasks. No emulsifiers or
solvents were used, but the solutions were dispersed by stirring to achieve a homogeneous solution of the test item.
The expiry date of the reference item refers to the storage in the container. At test start (weighing of test
item and reference item), the reference item was durable. The reference item expired not until it was in test solution.
Incubation:
The closed test flasks were incubated in a climatised chamber under continuous stirring. The consumpti
on of oxygen was determined by measuring the change of pressure in the flasks. Evolved carbon dioxide
was absorbed in an aqueous solution (45%) of potassium hydroxide.
Test Duration:
28 days
Measurement of Oxygen:
The change of pressure in the test flasks was measured by means of a manometric method (BSB/BODSensor-
System, Aqualytic Dortmund, Germany) each day.
Temperature:
The temperature was recorded by means of the automated software AMR Wincontrol©.
pH-Value:
pH-values were measured in procedure control, a separately prepared test flask with test item (to prevent
loss of test item in the test flasks) and a separately prepared test flask without test item (control) at test
start and in all flasks at day 29 of the test, except in the abiotic and toxicity control, using a pH-electrode
WTW pH 340i.
Reference substance
- Reference substance:
- benzoic acid, sodium salt
Results and discussion
- Test performance:
- The test item never reached 10% biodegradation.
The mean biodegradation percentage at the end of the 28-day exposure period was 5% (ThODNO3).
If no nitrification is considered, the mean biodegradation was 7% (ThODNH4) after 28 days of incubation.
The degradation rate of Fluormorpholinyl-acrylaldehyd never reached 10%.
Therefore, Fluormorpholinylacrylaldehyd is considered to be not readily biodegradable.
% Degradation
- Key result
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 7
- Sampling time:
- 28 d
- Remarks on result:
- not readily biodegradable based on QSAR/QSPR prediction
BOD5 / COD results
- Results with reference substance:
- The reference item sodium benzoate was sufficiently degraded to 82% after 14 days and to 88% after 28 days of incubation.
The percentage biodegradation of the reference item confirms the suitability of the used aerobic activated sludge inoculum.
Any other information on results incl. tables
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- The degradation rate of Fluormorpholinyl-acrylaldehyd never reached 10%.
Therefore, Fluormorpholinylacrylaldehyd is considered to be not readily biodegradable. - Executive summary:
Biodegradation of Fluormorpholinylacrylaldehyd:
Nitrogen is part of the molecular structure of the test item; therefore the evaluation of biodegradation has to be based on ThODNH4 and ThODNO3.
The criterion for ready biodegradability under the conditions of a manometric respirometry test is the degradation of the test item of at least 60%, reached within a 10-day window; the 10-day window starts when the degradation of the test item reaches at least 10% degradation.
Fluormorpholinylacrylaldehyd never reached 10% biodegradation (ThODNH4, ThODNO3). The mean biodegradation at test end after 28 days was 7% (ThODNH4) and 5% (ThODNO3).
Therefore, Fluormorpholinylacrylaldehyd is considered to be not readily biodegradable based on ThODNH4 and ThODNO3.
Biodegradation of Sodium Benzoate:
The reference item sodium benzoate was sufficiently degraded to 82% after 14 days and to 88% after 28 days of incubation, thus confirming the suitability of the aerobic activated sludge inoculum used.
Biodegradation of the Toxicity Control:
In the toxicity control containing both, the test item and the reference item sodium benzoate, 51% (ThODNH4) biodegradation was noted within 14 days and 58% (ThODNH4) biodegradation after 28 days of incubation (45% and 52% based on ThODNO3). According to the test guidelines, the test item can be assumed to be not inhibitory to the aerobic activated sludge microorganisms because degradation was >25% within 14 days.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.