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Diss Factsheets
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EC number: 238-877-9 | CAS number: 14807-96-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sediment toxicity
Administrative data
Link to relevant study record(s)
- Endpoint:
- sediment toxicity: long-term
- Data waiving:
- other justification
- Justification for data waiving:
- other:
- Endpoint:
- sediment toxicity: long-term
- Remarks:
- (Q)SAR calculated endpoint
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- QSAR prediction: US EPA accepted QSAR method for chemicals properties assessment.
- Qualifier:
- according to guideline
- Guideline:
- other: QSAR model
- Principles of method if other than guideline:
- EPI Suite v 4.1/ECOSARv1.00
- GLP compliance:
- no
- Remarks:
- not applicable. QSAR model
- Analytical monitoring:
- not required
- Vehicle:
- no
- Test organisms (species):
- other: Earthworm
- Details on test organisms:
- no further information
- Study type:
- other: QSAR model
- Test type:
- other: QSAR model
- Water media type:
- freshwater
- Type of sediment:
- not specified
- Limit test:
- no
- Duration:
- 14 d
- Exposure phase:
- total exposure duration
- Hardness:
- not applicable to QSAR models
- Test temperature:
- not applicable to QSAR models
- pH:
- not applicable to QSAR models
- Dissolved oxygen:
- not applicable to QSAR models
- Salinity:
- not applicable to QSAR models
- Ammonia:
- not applicable to QSAR models
- Details on test conditions:
- Chem Name : Talc (Mg3H2(SiO3)4)
Molecular Wt: 379.27
Henry's LC : 5.54e-029 atm-m3/mole (calc VP/Wsol)
Vapor Press : 1.11e-022 mm Hg (Mpbpwin program)
Liquid VP : 1.15e-019 mm Hg (super-cooled)
Melting Pt : 330 deg C (Mpbpwin program)
Log Kow : -9.4 (Kowwin program)
Soil Koc : 31.82 (KOCWIN MCI method) - Reference substance (positive control):
- no
- Duration:
- 14 d
- Dose descriptor:
- LC50
- Effect conc.:
- 313.318 mg/kg sediment dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: (Q)SAR prediction
- Remarks on result:
- other: non-toxic , as determined by (Q)SAR
- Details on results:
- LC50 (14-day, earthworm)= 313.318 mg/L (ppm)
1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.
LC50 (14-day, earthworm)= 313.318 mg/kg soil dw
The ECOSAR QSAR model predicts that 14 -day LC50 value would to be 313.318 mg/L (ppm) for freshwater sediment.Predicted to be non-toxic at the limit of solubility and therefore the substance is non-toxic at the limit of LoS as determined by (Q)SAR - Validity criteria fulfilled:
- yes
- Remarks:
- US EPA accepted QSAR method for chemicals properties assessment.
- Conclusions:
- LC50 (14-day, earthworm)= 313.318 mg/L (ppm)
1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.
LC50 (14-day, earthworm)= 313.318 mg/kg soil dw
The ECOSAR QSAR model predicts that 14 -day LC50 value would to be 313.318 mg/L (ppm) for freshwater sediment.Predicted to be non-toxic at the limit of solubility and therefore the substance is non-toxic at the limit of LoS as determined by (Q)SAR - Executive summary:
The ECOSAR QSAR model predicts that 14 -day LC50 value would to be 313.318 mg/L (ppm) for freshwater sediment.Predicted to be non-toxic at the limit of solubility and therefore the substance is non-toxic at the limit of LoS as determined by (Q)SAR.
Referenceopen allclose all
Overview of QSARs estimations on sediment toxicity of
Talc (Mg3H2(SiO3)4)
Method
|
Results |
Remarks |
Reference |
QSAR estimate |
LC50 (14-day, earthworm)=313.318 mg/L (ppm)
|
Reliable with restrictions, QSAR estimated data |
ECOSAR Program (v1.00) |
LC50 (14-day, earthworm)= 313.318 mg/L (ppm)
Description of key information
Talc (Mg3H2(SiO3)4) is found abundantly in nature in soils and sediments. The material is an inorganic non-biodegradable substance, retaining its structure in the environment. At normal environmental pH’s this material is stable. In addition it is unlikely through normal use patterns that exposure to natural sediments would occur. Soil and sediment degradation studies are not considered to be applicable as the test material is essentially insoluble in water and consists of materials which occur naturally in these compartments.
The ECOSAR QSAR model predicts that 14 -day LC50 value would to be 313.318 mg/L (ppm) for freshwater sediment. Predicted to be non-toxic at the limit of solubility and therefore the substance is non-toxic at the limit of LoS as determined by (Q)SAR.
Key value for chemical safety assessment
- EC50 or LC50 for freshwater sediment:
- 313.318 mg/kg sediment dw
- EC50 or LC50 for marine water sediment:
- 31.33 mg/kg sediment dw
- EC10, LC10 or NOEC for freshwater sediment:
- 62.66 mg/kg sediment dw
- EC10, LC10 or NOEC for marine water sediment:
- 6.27 mg/kg sediment dw
Additional information
The available data for marine water sediment are limited and to obtaine the value for PNECs for saltwaters is taken account a assesment factor 10 to extrapolate to LC50 following the “Guidance on Information Requirement and Chemical Safety Assessment R.10: Characterisation of dose [concentration]- response for environment”and “Table R.10-5 Assessment factors proposed for deriving PNEC water for saltwater for different data sets”, to account for the possibility that greater taxonomic diversity in the marine environment makes it likely that some marine taxa may be more sensitive than the most sensitive freshwater taxa.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.