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EC number: 209-939-2 | CAS number: 598-55-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From May 5, 1982 to May 19, 1982
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted equivalent to OECD Guideline 402, in compliance with GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Methyl carbamate
- EC Number:
- 209-939-2
- EC Name:
- Methyl carbamate
- Cas Number:
- 598-55-0
- Molecular formula:
- C2H5NO2
- IUPAC Name:
- methyl carbamate
- Test material form:
- other: Solid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Albino New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Perfection Breeders, Douglassville, Pennsylvania
- Weight at study initiation: 2 - 3 Kg
- Housing: Rabbits were housed individually in cages sized in accordance with the "Guide for the Care andUse of Laboratory Animals" of the Institute of Laboratory Resources, National Research Council.
- Diet: Wayne rabbit ration, ad libitum
- Water: Fresh tap water, ad libitum
- Acclimation period: 5 d
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20°C±3°C
- Humidity (%): 30 to 70%
- Photoperiod: 12 h dark and 12 h light
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- physiological saline
- Remarks:
- Test substance was only moistened with physiological saline
- Details on dermal exposure:
- DERMAL EXPOSURE
24 h prior to testing, fur from the trunk of the animals was shaved. Immediately prior to dosing, the skin of the rabbits was abraded by making four epidermal incisions with a clean needle through the stratum corneum, but not deep enough to disturb the derma or produce bleeding. The test substance was applied directly onto the exposed skin of the animals taking care to spread the substance evenly over the entire abraded area.
TEST SITE
- Area of exposure: 10% of of the dorsal body surface area
- Type of wrap if used: The animals were wrapped with rubber dam and an ace bandage to retard evaporation
REMOVAL OF TEST SUBSTANCE
- Washing (if done): After 24 h of exposure, the rubber dam and ace bandage were removed and the test site was wiped to remove any remaining material
TEST MATERIAL
- Amount(s) applied: 2,000 mg/kg bw
VEHICLE
Test substance was used as received (moistened with physiological saline). - Duration of exposure:
- 24 h
- Doses:
- 2,000 mg/kg bw
- No. of animals per sex per dose:
- 5/sex/dose
- Details on study design:
- - Duration of observation period following administration: 14 d
- Frequency of observations: 2 and 4 h after the 24 h period of exposure, and twice daily thereafter for 14 d.
- Necropsy of survivors performed: Rabbits were sacrificed by CO2 inhalation on Day 14 and a gross necropsy was performed.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- None of the animals died during the study.
- Clinical signs:
- other: Slight erythema was visible on Day 1 and 2 of the study.
- Gross pathology:
- Terminal necropsy revealed no visible lesions in any of the animals.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute dermal LD50 of the test substance for male and female rabbits was determined to be ≥2,000 mg/kg bw.
- Executive summary:
A study was conducted to assess the acute dermal toxicity of the test substance on rabbits in equivalent to OECD Guideline 402, in compliance with GLP. Five male and five female rabbits were administered a single dose of the test substance at a level of 2,000 mg/kg bw. 24 h prior to dosing the fur from the trunk of each animal was shaved so that at least 10% of dorsal body surface area was available for test substance administration. Immediately prior to dosing, the skin of the rabbits was abraded by making four epidermal incisions with a clean needle through the stratum corneum, but not deep enough to disturb the derma or produce bleeding. Test substance was moistened with physiological saline and applied directly to abraded skin. Wrap of the rubber dam and ace bandage was used to retard evaporation. Following the 24 h exposure period, test substance was wiped off. All animals were observed at 2, 4 h interval and twice daily thereafter for 14 d. No animal died during the study. All rabbits were sacrificed by CO2 inhalation on Day 14 and a gross necropsy was performed. Only a slight erythema was visible on Day 1 and 2 of the study. No signs of edema were observed during the study. Terminal necropsy revealed no visible lesions in any of the animals. Under the study conditions, the acute dermal LD50of the test substance for male and female rabbits was determined to be ≥2,000 mg/kg bw (Mallory VT, 1982).
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