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EC number: 209-939-2 | CAS number: 598-55-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From September 18, 1987 to October 16, 1987
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to OECD Guideline 301D, in compliance with GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Methyl carbamate
- EC Number:
- 209-939-2
- EC Name:
- Methyl carbamate
- Cas Number:
- 598-55-0
- Molecular formula:
- C2H5NO2
- IUPAC Name:
- methyl carbamate
- Test material form:
- other: solid
Constituent 1
Study design
- Inoculum or test system:
- activated sludge (adaptation not specified)
- Details on inoculum:
- - Source of inoculum/activated sludge: Bergen County, New Jersey, MUA
- Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 3 mg/L
- Based on:
- test mat.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Composition of medium: Standard dilution water
- Test temperature: 20±1°C
- Continuous darkness: Yes
TEST SYSTEM
- Culturing apparatus: Flasks
- Number of culture flasks/concentration: 2
- Measuring equipment: YSI Dissolved Oxygen Analyzer 54A
SAMPLING
- Sampling frequency: 0, 5, 15 and 28 d
CONTROL AND BLANK SYSTEM
- Inoculum blank: Yes
- Abiotic sterile control: No
- Toxicity control: No
Reference substance
- Reference substance:
- aniline
- Remarks:
- 2 mg/L
Results and discussion
- Test performance:
- A 3 mg/L of test substance was inoculated with activated sludge bacteria and kept in closed bottles in the dark in a constant temperature at 20±1°C. A control flask with dilution water and inoculum and another flask with aniline (reference substance) were run in parallel. Dissolved oxygen measurement was done at different intervals i.e. 0, 5, 15 and 28 d.
% Degradationopen allclose all
- Parameter:
- % degradation (O2 consumption)
- Value:
- 15.7
- Sampling time:
- 5 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 42.5
- Sampling time:
- 15 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 47
- Sampling time:
- 28 d
- Details on results:
- Test substance was biodegraded to 47% in 28d.
BOD5 / COD results
- Results with reference substance:
- Reference substance i.e. aniline was degraded to 95% in 28 d.
Any other information on results incl. tables
Table 1: Dissolved Oxygen Measurements (mg O2/L)
Medium |
Flask |
Day |
|||
0 |
5 |
15 |
28 |
||
Dilution water without inoculum |
C1 |
8.5 |
8.4 |
8.2 |
8.1 |
C2 |
8.5 |
8.5 |
8.3 |
8.1 |
|
Mean |
8.5 |
8.5 |
8.3 |
8.1 |
|
Dilution water with inoculum |
C3 |
9.0 |
8.8 |
8.2 |
8.0 |
C4 |
9.0 |
8.9 |
7.8 |
8.2 |
|
Mean |
9.0 |
8.9 |
8.0 |
8.1 |
|
Test substance (3 mg/L) with inoculum |
T1 |
9.0 |
7.9 |
5.8 |
5.8 |
T2 |
9.0 |
8.4 |
6.4 |
6.2 |
|
Mean |
9.0 |
8.2 |
6.1 |
6.0 |
|
Reference substance (2 mg/L) with inoculum |
R1 |
9.0 |
6.1 |
3.7 |
2.2 |
R2 |
9.0 |
6.4 |
3.3 |
2.2 |
|
Mean |
9.0 |
6.3 |
3.5 |
2.2 |
Table 2: Mean oxygen depletion and percent biodegradation
Medium |
Measurement |
Day |
||
5 |
15 |
28 |
||
Dilution water without inoculum |
O2depletion (mg O2/L) |
0 |
0.2 |
0.4 |
Dilution water with inoculum |
O2depletion (mg O2/L) |
0.1 |
1.0 |
0.9 |
Test substance (3 mg/L) with inoculum |
O2depletion (mg O2/L) |
0.8 |
2.9 |
3.0 |
TOD |
1.49 |
|||
%degradation |
15.7 |
42.5 |
47 |
|
Reference substance (2 mg/L) with inoculum |
O2depletion (mg O2/L) |
2.7 |
5.5 |
6.8 |
TOD |
3.09 |
|||
%degradation |
42 |
73 |
95 |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- other: not readily biodegradable
- Conclusions:
- The test substance was considered to be not readily biodegradable.
- Executive summary:
A study was performed to assess the ready biodegradability of the test substance according to OECD Guideline 301D, in compliance with GLP. 3 mg/L of test substance was inoculated with activated sludge bacteria and kept in closed bottles in the dark in a constant temperature at 20±1°C. A control with dilution water and inoculum, but without test substance was run parallel as a blank correction factor. A test with aniline (reference substance) was also run in parallel. The degradation was followed by oxygen analyses at different intervals i.e. 0, 5, 15 and 28 d. Based on dissolved oxygen measurements, mean oxygen depletion and percent biodegradation was calculated. Since aniline exceeded the pass level by degrading to 95%, this test can be considered valid. To be readily biodegradable, the percent degradation achieved should be 60% or more. However, test substance was biodegraded to 47% after 28d. Under the study conditions, the test substance was considered to be not readily biodegradable (Drozdowski D, 1988).
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