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Diss Factsheets
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EC number: 616-077-4 | CAS number: 74332-34-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- other: no GLP + only for 24h exposure
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- ISO 6341 (Water quality - Determination of the Inhibition of the Mobility of Daphnia magna Straus (Cladocera, Crustacea))
- Version / remarks:
- edited in May 1996
- GLP compliance:
- no
Test material
- Reference substance name:
- (17R)-17-hydroxy-10,13-dimethyl-17-(2-methyl-1,3-dioxolan-2-yl)-1,4,7,8,9,10,12,13,14,15,16,17-dodecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxolan]-11(2H)-one
- EC Number:
- 616-077-4
- Cas Number:
- 74332-34-6
- Molecular formula:
- C25H36O6
- IUPAC Name:
- (17R)-17-hydroxy-10,13-dimethyl-17-(2-methyl-1,3-dioxolan-2-yl)-1,4,7,8,9,10,12,13,14,15,16,17-dodecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxolan]-11(2H)-one
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Remarks:
- concentration of cetoxenone of the aqueous solution has been determined from carbon rate measured by carbon analyzer Shimadzu TOC 5050
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- The daphnies used are derived from a farm made from eggs from the toxicity screening test kit "Daphtoxkit F Magna".
Study design
- Test type:
- not specified
- Water media type:
- other: mineral water suspension
- Limit test:
- no
- Total exposure duration:
- 24 h
- Post exposure observation period:
- Visual observation after 24h of the immobilisation of Daphnies.
Test conditions
- Hardness:
- Not specified
- Test temperature:
- Ambient temperature
- pH:
- Not specified
- Dissolved oxygen:
- Not specified
- Nominal and measured concentrations:
- Nominal: 6.8, 3.4, 1.7, 0.85, 0.43, 0 mg/L
Measured: - - Details on test conditions:
- Ambiant temperature, protection from light
Assays are made in 4 replicates - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
Results and discussion
Effect concentrations
- Key result
- Duration:
- 24 h
- Dose descriptor:
- other: nominal concentration inducing 5% daphnies immobilisation
- Effect conc.:
- ca. 6.8 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- The most concentrated aqueous solution of cetoxetone (6.8 mg/L) triggers an immobilisation of 5% of daphnies. Cetoxenone is thus not toxic to daphnies.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Based on the experimental results, a saturated aqueous solution of cetoxenone at 6.8 mg/L is not toxic to daphnies.
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