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EC number: 231-760-3 | CAS number: 7722-64-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 27.3.-11.4.2006
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: This study was carried out in accordance with internationally valid GLP principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Potassium permanganate
- EC Number:
- 231-760-3
- EC Name:
- Potassium permanganate
- Cas Number:
- 7722-64-7
- Molecular formula:
- HMnO4.K
- IUPAC Name:
- potassium manganesoylolate
- Details on test material:
- - Name of test material (as cited in study report): Potassium permanganate
- Molecular formula (if other than submission substance): KMnO4
- Molecular weight (if other than submission substance): 158.03
- Batch No.: 69
- Substance type: technical product
- Physical state: solid crystals
- Analytical purity: 99.42 % wt.
- Impurities (identity and concentrations): Manganese dioxide ca 0.1 % wt.
- Appearance: dark violet-purple crystalline powder with bronze lustre
- pH: 1% solution-6.1
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: breeding farm BioTest s. r. o., Konárovice 281, Czech Republic
- Weight at study initiation: 2.6 kg
- Age at study initiation: 3-4 months
- Housing: individually in cages without bedding in conventional animal room
- Diet (e.g. ad libitum): pelleted standard diet TM-MAK 1 for rabbits and guinea-pigs ad libitum, made by Bergman, Kocanda Mill, 252 42 Jesenice u Prahy
- Water: drinking tap water, ad libitum (quality corresponding to Regulation No. 252/2004 Czech Coll. of Law)
- Acclimation period: 7days
- Identification of animals: code number on inner side of ear of animal, number of study on each cage
-Health condition: certificate of good health condition – from breeding farm; no signs of diseases were observed at clinical check-in,
in acclimatization period and before the start of experiment.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 17 - 23 °C, permanently monitored
- Humidity (%): 30 - 70 %, permanently monitored
- Air changes (per hr): approximatly 15 air changes per hour
- Photoperiod (hrs dark / hrs light): 12-hour light/dark cycle
Study time schedule
Animal supply: 20. 3. 2006
Experimental part of study: 27. 3. – 11. 4. 2006
Evaluation of results and final report elaboration: 12. 4. – 28. 4. 2006
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): The test substance was weighed (0.5 g) and applied in delivered form.
- Concentration (if solution): only moistened with smallest amount of water
- Application of the test substance: The test substance was covered by gauze patch, foil and cellulose cotton and held in place with non-irritating tape - Spofaplast - Duration of treatment / exposure:
- 3min
1hour
4 hour - Observation period:
- Skin reaction were evaluated after patch removal and at 1, 24, 48 and 72 hours after exposure.
The test animal was observed for 14 days of the observation period (according to guideline). - Number of animals:
- 1
- Details on study design:
- TEST SITE
- Area of exposure: fur from area 6x6 cm was removed
- % coverage: is not mentioned in study report
- Type of wrap if used: gauze patch, foil and cellulose cotton held in place with non-irritating tape Spofaplast
REMOVAL OF TEST SUBSTANCE
- Washing (if done): at the end of each exposure period patch was removed and remaining sample was washed with water
- Time after start of exposure: 1st patch - 3 minutes
2nd patch - 1 hours
3rd patch - 4 hours
Exposed rabbit was examined for signs of erythema and oedema at 1, 24, 48 and 72 hours after patch removal.
During the 14 days observation period, the lesion on the skin was almost healed without complications (gleet, erythema and oedema). It is possible to predict, that if the observation period will last for further few days, the lesion would be full healed.
SCORING SYSTEM: According to EU method B.4 Acute Toxicity: Dermal Irritation/Corrosion
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 1
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: full thickness destruction of skin occurred
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 1
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: full thickness destruction of skin occurred
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: full thickness destruction of skin occurred
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: full thickness destruction of skin occurred
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 48 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: full thickness destruction of skin occurred
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 48 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: full thickness destruction of skin occurred
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: full thickness destruction of skin occurred
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: full thickness destruction of skin occurred
- Irritant / corrosive response data:
- See table No. 1
- Other effects:
- No symptoms of systemic toxicity were observed in the animals during the test period and no mortality occurred.
No histopathology was performed.
Any other information on results incl. tables
Table No. 1 Skin reactions in experimental animals –grades
Time after 4-hours exposure |
Observation |
|
Rabbit No. 1 |
|
|
1 hour |
Erythema 0 Oedema 0 |
Full thickness destruction of skin tissue occurs |
24 hours |
Erythema 1 Oedema 0 |
Lesion – dry, without gleet Surroundings of the lesion – slight erythema, no oedema |
48 hours |
Erythema 1 Oedema 0 |
Lesion – dry, without gleet Surroundings of the lesion – slight erythema, no oedema |
72 hours |
Erythema 4 Oedema 0 |
Lesion - dry, crust, eschar formation |
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The test substance Potassium permanganate was tested for acute dermal irritation/corrosion.
After 4-hour exposure of the test substance on the intact skin of the test animal, full thickness destruction of skin tissue occurs. Then the testing was stopped – no other animal was used.
No extinction of corrosive lesions was recorded in 72 hours after exposure, the test animal was then observed until the end of observation period (14 days). During the 14-day observation period, the lesions on the skin were almost healed without complications.
No other signs of intoxication were observed. - Executive summary:
The test substance Potassium permanganate was tested in the study for acute dermal irritation/corrosion. Rabbit (New Zealand Albino breed) was used for the test.
Test was performed according to EU method B.4 Acute Toxicity: Dermal Irritation/Corrosion, which is analogous to OECD Test Guideline No. 404 Acute Dermal Irritation/Corrosion.
One rabbit was exposed to 0.5 g of the test substance, applied onto clipped skin for 3 minutes, 1 hour and 4 hours using a semi-occlusive dressing. Skin reactions were evaluated after patch removal and at 1, 24, 48 and 72 hours after exposure.
At 3-minute and 1-hour exposure no skin lesions were observed after removing of the patch.
After 4-hour exposure of the test substance on the intact skin of the test animal, full thickness destruction of skin tissue occurs. Then the testing was stopped – no other animal was used.
No extinction of corrosive lesions was recorded in 72 hours after exposure, the test animal was then observed until the end of observation period (14 days). During the 14-day observation period, the lesions on the skin were almost healed without complications.
No other signs of intoxication were observed.
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