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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
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Diss Factsheets
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EC number: 203-489-0 | CAS number: 107-41-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Fish LC50 is 8510 mg/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- LC50
- Effect concentration:
- 8 510 mg/L
Additional information
Hexylene glycol was reported to have low acute toxicity to various fish species with 96-hour LC50 values well above 5000 mg/L.
An acute toxicity study was performed to assess the acute aquatic toxicity of hexylene glycol (amongst other chemicals) to 10 aquatic species (fish, crustaceans, chironomid and amphibian) (Thurston et al., 1984). Testing method followed was similar to OECD Guideline 203. Fish were exposed to a range of hexylene glycol concentrations in freshwater and under continually aerated and flow-through conditions for a period of 96 hours. The lowest 96-hour LC50 of hexylene glycol was determined to be 8510 mg/L in Gambusia affinis. No other information was available.
The acute aquatic toxicity of hexylene glycol was also assessed in other studies in which no guidelines were followed but experimental details are provided allowing to conclude that the tests have been properly carried out. The results of these studies support the low acute toxicity of hexylene glycol to fish.
Other studies included acute toxicity tests conducted in Lepomis macrochirus under freshwater conditions, in Menidia beryllina under salt water conditions, and in Alburnus alburnus under static conditions in brackish water. Under their respective test conditions, the 96-hour LC50 of hexylene glycol was determined to be greater than 10 000 ppm in Lepomis macrochirus based on measured concentrations (Dawson et al., 1975), equal to 10 000 mg/L in Menidia beryllina based on measured concentrations (Dawson et al., 1975), and equal to 8000 mg/L in Alburnus alburnus based on nominal concentrations (Linden et al., 1979).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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