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EC number: 203-268-9 | CAS number: 105-08-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 24-hour application followed by 14-day observation period
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study conducted prior to introduction of the Good Laboratory Practices regulations. The study was conducted according to an internal Eastman Kodak Company method, developed prior to established guidelines, but according to acceptable scientific standard methods in use at the time the study was conducted. The results of this study are valid insofar as the conditions of exposure are at least as stringent as modern guidelines.
Data source
Reference
- Reference Type:
- other: Eastman Kodak Company Summary Report
- Title:
- Unnamed
- Year:
- 1 962
- Report date:
- 1962
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Deviations:
- not specified
- Principles of method if other than guideline:
- Method is an in vivo study using three guinea pigs. Following depilation of the abdomen of each animal, a single dose of 5.0, 10.0, or 20.0 mL/kg bw of the test material (received as a slurry in 1-3% methanol) was applied under an occlusive cuff prepared from a pad of gauze held in place with an impervious cuff made of rubber dental dam. The cuff was wrapped securely around the torso and held in place using non-irritating tape. Animals were exposed to the test material for 24 hours, then cuffs were removed; animals were observed following removal of the cuff, and on Days 7 and 14. In addition to observations for mortality, dermal reactions and weight changes were also recorded.
- GLP compliance:
- no
- Test type:
- other: Study conducted according to an internal Eastman Kodak Company laboratory method.
- Limit test:
- no
Test material
- Reference substance name:
- Cyclohex-1,4-ylenedimethanol
- EC Number:
- 203-268-9
- EC Name:
- Cyclohex-1,4-ylenedimethanol
- Cas Number:
- 105-08-8
- Molecular formula:
- C8H16O2
- IUPAC Name:
- cyclohexane-1,4-diyldimethanol
- Reference substance name:
- [4-(hydroxymethyl)cyclohexyl]methanol
- IUPAC Name:
- [4-(hydroxymethyl)cyclohexyl]methanol
- Reference substance name:
- Cyclohexane-1,4-dimethanol; 1,4-Bis(hydroxymethyl)cyclohexane; CHDM
- IUPAC Name:
- Cyclohexane-1,4-dimethanol; 1,4-Bis(hydroxymethyl)cyclohexane; CHDM
- Details on test material:
- no data
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- guinea pig
- Strain:
- Hartley
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- other: Test material administered as a slurry in 1-3% methanol.
- Details on dermal exposure:
- Following depilation of each animal's abdomen, a single dose of 5.0, 10.0, or 20.0 mL/kg bw of the test material (slurry in 1-3% methanol) was applied under an occlusive cuff and wrap. After a 24 hour exposure period, the cuffs and wrappings were removed.
- Duration of exposure:
- 24 hours
- Doses:
- One animal each was exposed to a single dose of 5, 10, or 20 mL/kg bw of the test substance as a slurry in 1-3% methanol.
- No. of animals per sex per dose:
- 1 animal/dose (sex not determined)
- Control animals:
- no
- Details on study design:
- Three guinea pigs (sex, age, and initial weights not provided) were used. Following depilation of the guinea pig abdomens, a single dose of 5.0, 10.0, or 20.0 mL/kg bw of the test material (slurry in 1-3% methanol) was applied under an occlusive wrap prepared from a pad of gauze held in place with an impervious cuff made of rubber dental dam material. The cuff was wrapped securely around the torso of the guinea pig and held in place with non-irritating tape. Animals were exposed for 24 hours, then the cuffs were removed. Animals were observed following removal of the cuff, and on Days 7 and 14. In addition to observations for mortality, dermal reactions were also noted. Guinea pigs were weighed prior to administration of the test substance and at termination of the 14-day observation period.
- Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LDLo
- Effect level:
- > 20 mL/kg bw
- Remarks on result:
- other: The dose levels used in this study are significantly higher than those used for present-day guideline studies.
- Mortality:
- None
- Clinical signs:
- other: No signs of test material absorption or systemic toxicity were noted during the study. Signs of irritation at the application site were limited to slight edema and slight erythema.
- Gross pathology:
- Not performed
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Conclusions:
- 1,4-Cyclohexanedimethanol was not acutely toxic by the dermal route in guinea pigs under conditions used in this study. The dermal LDLo in guinea pigs was > 20.0 mL/kg bw.
Based on an acute dermal LDLo value of > 20.0 mL/kg bw in guinea pigs, 1,4-cyclohexanedimethanol is not classified for Acute Toxicity by the dermal route under GHS. In the absence of signs of systemic toxicity and/or skin absorption, 1,4-cyclohexanedimethanol is not classified under GHS for Specific Target Organ Toxicity – Single Exposure. Based on minimal signs of irritation after an extreme exposure period of 24 hours under an occlusive wrap to depilated abdominal skin of guinea pigs, 1,4-cyclohexanedimethanol is not classifiable for Skin Irritation/Corrosion according to GHS. - Executive summary:
In an acute dermal toxicity study, 3 Hartley guinea pigs were exposed to 5, 10 or 20 mL/kg bw of 1,4-cyclohexanedimethanol (slurry in 1-3% methanol) under occlusive contact for 24 hours. Based on a specific gravity of 1.04 for the undiluted test material, the doses of 1,4-cyclohexanedimethanol administered to guinea pigs in this study were significantly higher than those used in present day protocols. Under the conditions of this study, no deaths occurred and the dermal LDLo was considered to be > 20.0 mL/kg bw. No signs of skin absorption or systemic toxicity were evident during the study. At the application sites, signs of skin irritation were limited to slight edema and slight erythema. Desquamation at the application sites was noted at the 1-week observations. At termination of the 2-week study, all animals appeared normal. A body weight gain was noted for all animals over the 2-week observation period. Based on the results of this study, 1,4-cyclohexanedimethanol presents a low toxicity hazard upon skin contact under conditions of normal use.
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