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EC number: 247-045-4 | CAS number: 25498-49-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1984
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to EPA/OPP guideline and in accordance with GLP
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-4 (Acute Eye Irritation)
- Principles of method if other than guideline:
- Guideline study
- GLP compliance:
- yes
Test material
- Reference substance name:
- [2-(2-methoxymethylethoxy)methylethoxy]propanol
- EC Number:
- 247-045-4
- EC Name:
- [2-(2-methoxymethylethoxy)methylethoxy]propanol
- Cas Number:
- 25498-49-1
- Molecular formula:
- C10H22O4
- IUPAC Name:
- [2-(2-Methoxymethylethoxy)methylethoxy]propanol
- Details on test material:
- - Name of test material (as cited in study report): A273956
- Physical state: Liquid
- pH: 6.0
- Storage condition of test material: Ambient laboratory conditions
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Clerco Research Farm, Cincinnati, OH.
- Age at study initiation: Young adult
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature: 67±5 Deg. F
- Humidity (%): 30-70%
- Photoperiod (hrs dark / hrs light): 12 hrs dark / 12 hrs light
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): One-tenth (0.1) millitier/eye - Duration of treatment / exposure:
- 0.1 ml of material was placed in the right eye .
The treated eyes of 6 rabbits were unwashed.
The treated eyes of 3 rabbits were washed for 1 minute with lukewarm tap water at a rate of approximately 1 liter per minute beginning approximately 30 seconds after installation of the test article. - Observation period (in vivo):
- 1, 24, and 48 hours and 72 hours.
- Number of animals or in vitro replicates:
- Unwashed eye group-6 animals
Washed eye group- 3 animals - Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing : The treated eyes of 3 rabbits were washed for 1 minute with lukewarm tap water at a rate of approximately 1 liter per minute beginning approximately 30 seconds after installation of the test article.
- Time after start of exposure: The right eye of each animal was examined for ocular irritation and lesions at 1 hour
(± 15 minutes), and at 24, 48, and 72 hours (± 2 hours at each interval).
SCORING SYSTEM: Draize Score
TOOL USED TO ASSESS SCORE: A pocket flashlight without magnification was used at all evaluation intervals, and a 2% sodium fluorescein solution in deionized water was used at all evaluations except for those done at 1 hour after instillation.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- over 6 animals
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0
- Remarks on result:
- other: unwashed eye group
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- over 6 animals
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0
- Remarks on result:
- other: washed eye group
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- over 6 animals
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0
- Remarks on result:
- other: unwashed eye group
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- over 6 animals
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0
- Remarks on result:
- other: washed eye group
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- over 6 animals
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0.4
- Reversibility:
- fully reversible within: 48 hours
- Remarks on result:
- other: unwashed eye group
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- over 6 animals
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0.3
- Reversibility:
- fully reversible within: 48 hours
- Remarks on result:
- other: washed eye group
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- over 6 animals
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0.6
- Reversibility:
- fully reversible within: 72 hours
- Remarks on result:
- other: unwashed eye group
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- over 6 animals
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0.3
- Reversibility:
- fully reversible within: 48 hours
- Remarks on result:
- other: washed eye group
- Other effects:
- None
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- According to the annex VI of the council directive 67/548 EEC (amended by directive 83/467 EEC) the average scores over all animals for cornea opacity, iris lesions, conjunctivae and chemosis were 0, 0, 0.4 and 0.6, respectively at 24, 48 and 72 hours. According to EEC criteria no classification for eye irritancy is required.
- Executive summary:
The test article, A273956, was evaluated for primary eye irritation after instillation in the right eyes of 9 rabbits.
This study was designed to comply with the procedure described in EPA/OPP Guidelines, 1982.
The eyes of 3 of these 9 rabbits were washed with lukewarm tap water after instillation. The treated eyes of all animals (washed and Unwashed) were evaluated at 1, 24, 48, and 72 hours after installation.
No mortalities or abnormal clinical signs were observed during the study. Blistering of the conjunctivae was noted for all the unwashed and washed group animals at the one hour evaluation, which was fully reversible before 72 hours.
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