Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 247-045-4 | CAS number: 25498-49-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1977
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP study equivalent to OECD guideline 402.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- [2-(2-methoxymethylethoxy)methylethoxy]propanol
- EC Number:
- 247-045-4
- EC Name:
- [2-(2-methoxymethylethoxy)methylethoxy]propanol
- Cas Number:
- 25498-49-1
- Molecular formula:
- C10H22O4
- IUPAC Name:
- [2-(2-Methoxymethylethoxy)methylethoxy]propanol
- Details on test material:
- Propasol Solvent TM
Amount Received: 1 pint
Sample No. 40-130
ID: 511-01-1485
Receipt Date: March 22, 1977
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Albino (strain not specified)
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 3 to 5 months old
- Weight at study initiation: weight not specified
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Details on dermal exposure:
- For a period of 24 hour, TPM was applied under occlusion (impermeable wrap - polyethylene sheeting) to the clipped, intact skin of the trunk of male albino rabbits at dose levels of 8.0 or 16 milliliters TPM per kg body weight. These dose volumes correspond to 7.72 or 15.4 g/kg (7720 or 15400 mg/kg). Rabbits were restrained in an undefined manner. At the end of the 24-hour application period, excess TPM was removed and the rabbits were observed for mortality and signs of toxicity for an unspecified period thereafter (presumably up to 14 days).
- Duration of exposure:
- 24 hour
- Doses:
- 8.0 and 16.0 ml/kgbw. These dose volumes correspond to 7.72 or 15.4 g/kg (7720 or 15400 mg/kg).
- No. of animals per sex per dose:
- 4 per group
- Control animals:
- not specified
- Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 15 440 mg/kg bw
- Mortality:
- 16 ml/kg: 2/4
8 ml/kg: 0/4 - Clinical signs:
- other: The high dose of 16 ml/kg (15400 mg/kg) caused death in 2 of 4 rabbits on days 2 and 3. Non-survivors lost 80 and 113 grams of weight and one subject from this group had an unsteady gait and another was prostrate at 24 hours. At 8 ml/kg (7720 mg/kg),
- Gross pathology:
- At necropsy, non-survivors showed mottled livers, mottled spleens, and full bladders. Survivors exhibited pale and mottled kidneys.
- Other findings:
- None
Any other information on results incl. tables
LD50: 16 ml/kg or 15440 mg/kg
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The dermal LD50 of TPM is 16 ml/kg or 15400 mg/kg with a very broad 95% confidence interval ranging from 4.48 to 57.2 ml/kg, according to the authors, of the fractional mortality at the high dose. TPM shows a low order of acute dermal toxicity.
- Executive summary:
A sample of Propasol Solvent TM (sample no. 40-130) was evaluated for acute toxicity potential in male albino rabbits. 4 rabbits per group of 3 to 5 months old were used in the study.
For a period of 24 hour, TPM was applied under occlusion (impermeable wrap - polyethylene sheeting) to the clipped, intact skin of the trunk of male albino rabbits at dose levels of 8.0 or 16 milliliters TPM per kg body weight. These dose volumes correspond to 7.72 or 15.4 g/kg (7720 or 15400 mg/kg). Rabbits were restrained in an undefined manner. At the end of the 24-hour application period, excess TPM was removed and the rabbits were observed for mortality and signs of toxicity for an unspecified period thereafter (presumably up to 14 days)
The high dose of 16 ml/kg (15400 mg/kg) caused death in 2 of 4 rabbits on days 2 and 3. Non-survivors lost 80 and 113 grams of weight and one subject from this group had an unsteady gait and another was prostrate at 24 hours. At 8 ml/kg (7720 mg/kg), no rabbits died and no symptoms were reported.
At necropsy, non-survivors showed mottled livers, mottled spleens, and full bladders. Survivors exhibited pale and mottled kidneys.
The dermal LD50 of TPM is 16 ml/kg or 15400 mg/kg with a very broad 95% confidence interval ranging from 4.48 to 57.2 ml/kg, according to the authors, of the fractional mortality at the high dose. TPM shows a low order of acute dermal toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.