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EC number: 407-950-9 | CAS number: 895-85-2 INTEROX-PMBP-70W; INTEROX-PMPB-70W
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was performed under GLP according to protocol. It was reviewed in the HPV program and recorded in the OECD SIDS dossier as reliability 1.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Vehicle:
- no
- Test organisms (species):
- Oryzias latipes
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Nominal and measured concentrations:
- Nominal: 35.0, 45.5, 59.2, 76.9 and 100 mg/L
- Reference substance (positive control):
- not specified
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 64 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Validity criteria fulfilled:
- yes
- Conclusions:
- This study is reliable. It is performed according to OECD guideline 203 under GLP and it was reviewed during the HPV process. The calculated endpoints are adequate for C&L and risk assessment purposes.
- Executive summary:
An acute toxicity test of p-toluic acid was conducted for Oryzias latipes (MOE Japan, 2003). The exposure was undertaken under semi-static condition with every 24 hours renewal at the concentrations of 35.0, 45.5, 59.2, 76.9 and 100 mg/L in nominal with a blank control. No vehicle was used. Ten fish per concentration were used. The measured concentrations in each treatment at initial (just after renewal) and after a 24 hrs were 98.9 – 100.4 % and 99.3 – 102.4 % of the nominal, respectively. At the control and treatment groups up to 45.1 mg/L (in the mean measured concentration) no mortality were observed during a 96 h of test period. The mortalities at 58.9, 76.5 and 101.4 mg/L (mean measured concentrations) were 10, 100, and 100 %, respectively. Based on measured concentration the 96 h LC50(95% confidence limits) of 64 (57 – 74) mg/L was calculated by a probit method. In the test the pH of test water of 76.5 and 101.4 mg/L were 5.3 and 4.7, respectively. Thus the item was stable under the experimental condition. At these treatment groups all fish were died within 24 hours.The test is regarded as high reliability because no deviations from the OECD Test Guideline 203 occurred, although adjustment of pH was not undertaken.
Reference
Description of key information
An acute toxicity test of p-toluic acid was conducted for Oryzias latipes (MOE Japan, 2003). The exposure was undertaken under semi-static condition with every 24 hours renewal at the concentrations of 35.0, 45.5, 59.2, 76.9 and 100 mg/L in nominal with a blank control. No vehicle was used. Ten fish per concentration were used. The measured concentrations in each treatment at initial (just after renewal) and after a 24 hrs were 98.9 – 100.4 % and 99.3 – 102.4 % of the nominal, respectively. At the control and treatment groups up to 45.1 mg/L (in the mean measured concentration) no mortality were observed during a 96 h of test period. The mortalities at 58.9, 76.5 and 101.4 mg/L (mean measured concentrations) were 10, 100, and 100 %, respectively. Based on measured concentration the 96 h LC50(95% confidence limits) of 64 (57 – 74) mg/L was calculated by a probit method. In the test the pH of test water of 76.5 and 101.4 mg/L were 5.3 and 4.7, respectively. Thus the item was stable under the experimental condition. At these treatment groups all fish were died within 24 hours.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 64 mg/L
Additional information
Due to rapid hydrolysis of 895-85-2 (see van Dam, 2014), the aquatic results of p-toluic acid are considered most relevant.
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