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Diss Factsheets
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EC number: 240-759-7 | CAS number: 16712-64-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1983-09-13 - 1983-09-29
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Well documented study, performed to OECD Guideline, performed under GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 3-hydroxy-2-naphthoic acid
- EC Number:
- 202-180-8
- EC Name:
- 3-hydroxy-2-naphthoic acid
- Cas Number:
- 92-70-6
- IUPAC Name:
- 3-hydroxy-2-naphthoic acid
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): BONS TTR
- Molecular formula (if other than submission substance): HOC10H6CO2H
- Molecular weight (if other than submission substance): 188.18
- Physical state: Solid
- Analytical purity: Not given
- Impurities (identity and concentrations): 1% beta-naphthol
- Composition of test material, percentage of components:
- Purity test date: Not given
- Lot/batch No.: 1297/83
- Expiration date of the lot/batch: Not given
- Radiochemical purity (if radiolabelling): Not applicable
- Specific activity (if radiolabelling): Not applicable
- Locations of the label (if radiolabelling): Not applicable
- Expiration date of radiochemical substance (if radiolabelling): Not applicable
- Stability under test conditions: Not given
- Storage condition of test material: Stored at 22 degrees C in the dark.
- Other:
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: HOECHST AG breeding colony
- Weight at study initiation: 2,2 - 2,6 kg
- Housing: single cages
- Diet (e.g. ad libitum): Rabbit diet Altromin 2123, ad libitum
- Water (e.g. ad libitum): deionised, chlorinated, ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 +/-2
- Humidity (%): 55 +/-10
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- other: PEG 400
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 500 mg/patch suspended in 0.32 ml PEG 400
- Concentration (if solution):
VEHICLE
- Amount(s) applied (volume or weight with unit):
- Concentration (if solution):
- Lot/batch no. (if required):
- Purity: - Duration of treatment / exposure:
- Animals were exposed to test article for 4 hours.
- Observation period:
- Primary observation at 30-60 minutes after removal of patch, with subsequent observations at 24, 48 and 72 hours post patch-removal.
- Number of animals:
- 3 animals
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 x 2.5 cm patch
- % coverage: Not given
- Type of wrap if used: Cellulose acetate patch
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Not performed.
- Time after start of exposure: 4 hours
SCORING SYSTEM: Scored according to Draize. A test substance is considered to be a skin irritant if it causes an inflammation of the skin, the exposure time up to 4 hours to 24 hours or longer lasting, and corresponds to the following values: mean erythema score or edema score above 2.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal: 1, 2, 3 each
- Time point:
- other: mean of 24, 48 and 72 h
- Score:
- 0.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- edema score
- Basis:
- animal: 1, 2, 3 each
- Time point:
- other: mean of 24, 48, 72 h
- Score:
- 0.3
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks:
- 48 h
- Irritant / corrosive response data:
- erythema and edema recorded.
- Other effects:
- No other effects were reported
Any other information on results incl. tables
Average Values for Erythema and Eschar
Animal 1 | 0.3 |
Animal 2 | 0.3 |
Animal 3 | 0.3 |
Average for all Animals | 0.3 |
Average values for Edema
Animal 1 | 0.3 |
Animal 2 | 0.3 |
Animal 3 | 0.3 |
Average for all Animals | 0.3 |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information REGULATION (EC) No 1272/2008 Criteria used for interpretation of results: EU
- Conclusions:
- not irritating under the test conditions.
The mean Draize scores for erythema and edema derived from 24, 48 and 72 hour post treatment observation time points were 0.3 in each of three rabbits. All erythema and edema findings were completely reversible within 48 hours post patch removal. Based on these findings the test substance was considered "not irritant". - Executive summary:
- According to the classification criteria of the REGULATION (EC) No 1272/2008EC, and taking into account all relevant toxicological findings, the substance BONS TTR can be described as a not irritating.
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