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Diss Factsheets
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EC number: 209-750-5 | CAS number: 592-34-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP non-guideline, available as unpublished report, limitations restrictions in design and/or reporting.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 970
- Report date:
- 1970
- Reference Type:
- other: English translation (summary)
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
- Principles of method if other than guideline:
- According to BASF-internal standard: Five Kisslegg mice per sex per dose were exposed to the test substance, dissolved in an aqueous emulsion with Tragacanth, via intraperitoneal injection. After an observation period of 14 days animals were necropsied.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Butyl chloroformate
- EC Number:
- 209-750-5
- EC Name:
- Butyl chloroformate
- Cas Number:
- 592-34-7
- Molecular formula:
- C5H9ClO2
- IUPAC Name:
- butyl carbonochloridate
- Details on test material:
- - Name of the test substance used in the study report: n-Butylchlorkohlensäureester; Chloroformic acid butyl ester
- Physical state: liquid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: Kisslegg mice
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: aqueous emulsion with Tragacanth
- Details on exposure:
- The test concentrations used were 0.1, 0.5 and 1% (V/V).
- Doses:
- 6.4, 8, 10, 25, 50 (0.1% substance preparation), 12.5, 25 (0.5% substance preparation), 50 mm3/kg (1% test substance preparation)
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- < 13 mg/kg bw
- Based on:
- other: 0.5% test substance preparation
- Remarks on result:
- other: original value: <12.5 mm3/kg
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 53 mg/kg bw
- Based on:
- other: 0.1% test substance preparation
- Remarks on result:
- other: original value: >50 mm3/kg
- Mortality:
- 0.1% test substance preparation:
- 6.4, 8 and 10 mm3/kg: no deaths after 14 days;
- 25 and 50 mm3/kg: 1/10 after 14 days;
0.5% test substance preparation:
- 12.5 mm3/kg: 8/10 after 14 days;
- 25 mm3/kg: 9/10 after 14 days;
1% test substance preparation:
- 50 mm3/kg: 10/10 after 14 days - Clinical signs:
- - 1% and 0.5% test substance preparation: Immediately after the injection restlessness, long legged gait, sunken flanks, rapid breathing and stretching was observed. During the observation period the surviving animals showed prone position, dyspnea, heavily ruffled fur, sticky eyes, slight apathy, slight trembling, and quiet behavior. From day 13 no effects were observed.
- 0.1% test substance preparation: (50 and 25 cmm/kg): Immediately after the injection rapid breathing, delayed movements of the extremities. After 5 hours quiet behavior, dyspnea and closed eyes were observed. After six days no effects were observed.
- 0.1% test substance preparation: (10, 8, and 6.4 cmm/kg): Immediately after the injection rapid breathing, delayed movements of the extremities, restlessness, long legged gait, and stretching was observed. The next day rapid breathing and ruffled fur was observed. After five days no effects were observed. - Gross pathology:
- Adhesions in the abdominal cavity were observed.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.