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EC number: 207-228-1 | CAS number: 454-89-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
- Endpoint:
- fish early-life stage toxicity
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 992
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPPTS 850.1400 (Fish Early-life Stage Toxicity Test)
- GLP compliance:
- no
Test material
- Reference substance name:
- α,α,α-trifluoro-3-tolualdehyde
- EC Number:
- 207-228-1
- EC Name:
- α,α,α-trifluoro-3-tolualdehyde
- Cas Number:
- 454-89-7
- Molecular formula:
- C8H5F3O
- IUPAC Name:
- 3-(trifluoromethyl)benzaldehyde
- Test material form:
- liquid
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
- Details on test solutions:
- Stock Solution Preparation: approx. 125.0 µg/L diluted
Test organisms
- Test organisms (species):
- Pimephales promelas
- Details on test organisms:
- Fathead minnow embryos that were < 24 hr old were obtained from the University of Wisconsin-Superior culture unit, and all embryo masses were pooled. Approximately 42-47 embryos were randomly selected and transferred to the exposure chamber (84-94 fry/chamber). At hatch, 15 fry from each egg cup and its replicate were randomly selected and transferred to each exposure chamber.
Study design
- Test type:
- flow-through
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 33 d
Test conditions
- Hardness:
- 51.73 CaC03 (mg/L)
- Test temperature:
- 25.58 °C (mean value)
- pH:
- 7.22 (mean value)
- Dissolved oxygen:
- 6.90 mg/L (mean value)
- Salinity:
- n.a.
- Conductivity:
- not recorded
- Nominal and measured concentrations:
- Nominal test concentration (µg/L): 52, 104, 208, 417 and 833
equal
Measured uncorrected concentration (µg/L) (mean value out of two determinations): 53.6, 57.8, 66.6, 116.5 and 285.3 - Details on test conditions:
- The test was performed with a modified Benoit flow-through mini-diluter.
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 33 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 285 µg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- number hatched
- Duration:
- 33 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 117 µg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 33 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 117 µg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- weight
- Remarks:
- wet
- Duration:
- 33 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 117 µg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- weight
- Remarks:
- dry
- Duration:
- 33 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 117 µg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- length
- Remarks:
- standard
- Duration:
- 33 d
- Dose descriptor:
- LOEC
- Effect conc.:
- 285 µg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- other: Percent survival; wet weight; dry weight; length standard
- Details on results:
- - Average Spike Recovery (%):100.00 n= 0
- Duplicate Analysis Agreement(%): 83.8 n= 11 - Reported statistics and error estimates:
- Percent Normal Larvae at Hatch and Percent Survival data were transformed using the Freeman-Tukey Arc sine method prior to analysis by William's TeSt. The
Wet Weight and Length data were analyzed using William's Test (P<0.05), while the Dry Weight data were analyzed using Dunnett's Test.
Any other information on results incl. tables
Juvenile growth at 33 days:
- wet weight (mg): 70.1 -146.0
- dry weight (mg): 13.1 -30.4
- length (mm): 14.7 -19.6
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- In the test with 3-(Trifluoromethyl)benzaldehyde (CAS no. 454-89-7) with fish (Pimephales promelas) a NOEC of 117 µg/L and a LOEC of 285 µg/L after 33 dyas are obtained concerning the percent survival, wet weight, dry weight and length standard of the juvenile growth. The test guideline is equivalent to EPA OPPTS 850.1400 (Fish Early-life Stage Toxicity Test).
- Executive summary:
In the test with 3-(Trifluoromethyl)benzaldehyde (CAS no. 454-89-7) with fish (Pimephales promelas) a NOEC of 117 µg/L and a LOEC of 285 µg/L after 33 dyas are obtained concerning the percent survival, wet weight, dry weight and length standard of the juvenile growth. The test guideline is equivalent to EPA OPPTS 850.1400 (Fish Early-life Stage Toxicity Test).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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