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EC number: 204-634-0 | CAS number: 123-54-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted standards, well documented and acceptable for assessment.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 2 001
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 986
Materials and methods
- Principles of method if other than guideline:
- Draize test.
0.5 mL undiluted 2,4-pentanedione were applied to the clipped, intact dorsal skin of 6 New Zealand White rabbits (3 males and 3 females) under a gauze patch and were loosely covered with impervious sheeting. Skin reaction was scored by the method of Draize at 1 hour and 1, 2, 3, 7 and 14 days after removal of the dressing. - GLP compliance:
- not specified
Test material
- Details on test material:
- Purity: >99%
Physical state: yellow, transparent non-viscous liquid
Lot No.: 496-500
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.5 mL
- Duration of treatment / exposure:
- 4 h
- Observation period:
- 14 days
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Dorsal skin
- Type of wrap if used: gauze patch
REMOVAL OF TEST SUBSTANCE: no data
SCORING SYSTEM: Draize scheme
-Observations performed after 1hour and 1, 2, 3, 7 and 14 days.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.8
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: On day 7 only mild desquamation was observed.
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.4
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: On day 7 only mild desquamation was observed.
- Irritant / corrosive response data:
- One hour after removal of the occlusive dressing slight erythema were detectable in 5/6 animals (average score 0.8). After 24 hours erythema were detectable in 6/6 animals (average score 1.0).
Moderate edema formation was observed in 1/6 rabbits and slight edema formation in 5/6 rabbits one hour after removal of the occlusive dressing (average score 1.2). After 24 hours slight edema were still present in 5/6 rabbits (average score 0.8). After 48 and 72 hours five and three animals revealed just detectable erythema, respectively (average scores 0.8 and 0.5). Mild edema were observable at 48 and 72 hours in two and one animals, respectively (average scores 0.3 and 0.2). With the exception of mild desquamation no effects were observed on day 7. Other effects were not detectable at any observation time.
Any other information on results incl. tables
Table 1: Individual erythema and edema score after 5 h up to 14 days (d: desquamation):
Exposure time 4 h |
|
|||||
|
Animal 1 |
Animal 2 |
Animal 3 |
Animal 4 |
Animal 5 |
Animal 6 |
|
5 h |
|
|
|
|
|
erythema |
1 |
1 |
1 |
1 |
1 |
0 |
edema |
1 |
2 |
1 |
1 |
1 |
1 |
|
|
|
|
|
|
|
|
24 h |
|
|
|
|
|
erythema |
1 |
1 |
1 |
1 |
1 |
1 |
edema |
1 |
1 |
1 |
1 |
0 |
1 |
|
48 h |
|
|
|
|
|
erythema |
1 |
1 |
1 |
1 |
0 |
1 |
edema |
0 |
1 |
0 |
1 |
0 |
0 |
|
72 h |
|
|
|
|
|
erythema |
0 |
1 |
1 |
1 |
0 |
0 |
edema |
0 |
1 |
0 |
0 |
0 |
0 |
|
|
|
|
|
|
|
|
7 d |
|
|
|
|
|
erythema |
0 |
0 |
0 |
0 |
0 |
0 |
edema |
0 |
0, d |
0, d |
0, d |
0, d |
0, d |
|
14 d |
|
|
|
|
|
erythema |
0 |
0 |
0 |
0 |
0 |
0 |
edema |
0 |
0 |
0 |
0 |
0 |
0 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the evaluated conditions, the test material does not show a skin irritation potential.
- Executive summary:
6 New Zealand White rabbits were dermally exposed to 0.5 mL undiluted test substance under occlusive conditions for 4 hours. Readings were performed after 1 hour and 1, 2, 3, 7, and 14 days. One hour after removal of the occlusive dressing slight erythema were detectable in 5/6 animals (average score 0.8). After 24 hours erythema were detectable in 6/6 animals (average score 1.0).
Moderate edema formation was observed in 1/6 rabbits and slight edema formation in 5/6 rabbits one hour after removal of the occlusive dressing (average score 1.2). After 24 hours slight edema were still present in 5/6 rabbits (average score 0.8). After 48 and 72 hours five and three animals revealed just detectable erythema, respectively (average scores 0.8 and 0.5). Mild edema were observable at 48 and 72 hours in two and one animals, respectively (average scores 0.3 and 0.2). With the exception of mild desquamation no effects were observed on day 7. Other effects were not detectable at any observation time.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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