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EC number: 429-600-4
CAS number: 1026988-42-0
Basazol Gelb 8511 was tested in a 28 day and 90 d oral gavage study. In the 90 d study 2/10 males and 7/19 females of the high dose (180/120 mg/kg) died prematureley due to chronic tympania. The NOAEL was 10 mg/kg bw.
The data discussed in this section were derived from toxicity studies
with the hydrochloride of the same azo dye (read-across to Basisch Gelb
8511, CAS 118208-02-9).
The oral administration of Basazol Gelb 8511 caused lethality at 180/120
mg/kg body weight due to chronic tympania. Toxicity was further
characterized by mild neutrophilia in both sexes indicating a slight
inflammatory reaction. Discoloration of urine and/or feces was seen in
all treatment groups. This was, however, related to the physical
properties of the test compound (dye stuff) but does not represent a
toxicologically relevant effect. The affection of the respiratory system
is probably due to an unintentional aspiration of the test substance as
a consequence of attempts to vomit the test substance. It may therefore
be addressed as a substance-related effect, but not an adverse effect.
Thus, under the conditions of this study, the no observed adverse effect
level (NOAEL) was 10 mg/kg bodyweight/day in both sexes .
EU classification according to Annex VI of the Directive 67/548/EEC:
GHS classification according to Annex I 1272/2008 CLP (EU GHS):
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