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Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Administrative data

Endpoint:
bioaccumulation in aquatic species: fish
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP Guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1998
Report Date:
1998

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 305 C (Bioaccumulation: Test for the Degree of Bioconcentration in Fish)
GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): 8511HC
- Molecular formula (if other than submission substance): C20H14O6N4
- Smiles notation (if other than submission substance): Oc1ccccc1N=Nc3ccc(O)c(N=Nc2ccccc2O)c3O

Test organisms

Test organisms (species):
Cyprinus carpio
Details on test organisms:
TEST ORGANISM
- Common name: Carp
- Length at study initiation: about 10 cm
- Weight at study initiation: 20-40 g


ACCLIMATION
- Acclimation period: > 1 week
- Type and amount of food: Minipet, Kyorin Co ., Ltd ., Japan
- Feeding frequency: day at the rate of about 2% of their total biomass per feeding, except weekends and holidays
- Health during acclimation (any mortality observed): Mortality of fish during the week before testing : 0%

Study design

Route of exposure:
aqueous
Test type:
flow-through
Water / sediment media type:
natural water: freshwater
Total exposure / uptake duration:
8 wk

Test conditions

Test temperature:
24 ± 0.5 °C
Dissolved oxygen:
5.0 8.3 mg/L
Details on test conditions:
TEST SYSTEM
- Test vessel:
- Material, fill volume: glass tanks, volum = 80 L
- Renewal rate of test solution (frequency/flow rate): 800 L/Day
- No. of vessels per concentration (replicates): 15 - 20
- No. of vessels per control / vehicle control (replicates): 15 - 20
- No. of organisms per vessel: 12-15


TEST MEDIUM / WATER PARAMETERS
- Holding medium different from test medium: no
- Intervals of water quality measurement: twice a week
Nominal and measured concentrations:
nominal concentrations: 0.1 and 0.01 mg/L
Reference substance (positive control):
not specified

Results and discussion

Bioaccumulation factoropen allclose all
Type:
BCF
Value:
< 2
Remarks on result:
other: Conc.in environment / dose:0.1 mg/L
Type:
BCF
Value:
< 15
Remarks on result:
other: Conc.in environment / dose:0.01 mg/L

Applicant's summary and conclusion