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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Documentation very brief

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1949
Report date:
1949
Reference Type:
publication
Title:
Range-finding toxicity data: list IV
Author:
Smyth HF Jr, Carpenter CP and Weil CS
Year:
1951
Bibliographic source:
Arch. Ind. Hyg. Occup. Med. 4, 119-122

Materials and methods

Principles of method if other than guideline:
Method: other: Smyth HF Jr, Carpenter CP (1944): The place of the range finding test in the industrial toxicology laboratory. J. Ind. Hyg. Toxicol. 26, 269-273 and subsequent updates
GLP compliance:
no
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
1,2,3,4-tetrahydronaphthalene
EC Number:
204-340-2
EC Name:
1,2,3,4-tetrahydronaphthalene
Cas Number:
119-64-2
Molecular formula:
C10H12
IUPAC Name:
1,2,3,4-tetrahydronaphthalene
Details on test material:
tetrahydronaphthalene procured from Eastman Kodak Co. under their number P550 on 10 Jan. 1949. No data on purity

Test animals

Species:
rat
Strain:
not specified
Sex:
male

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
not specified
Details on inhalation exposure:
Animals were exposed to saturated vapor at 20°C or a mist generated at 170°C
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
8 h
Concentrations:
ca. 1.8 mg/l and higher
No. of animals per sex per dose:
6
Control animals:
not specified

Results and discussion

Effect levels
Key result
Sex:
male
Dose descriptor:
LC50
Effect level:
> 1.8 mg/L air
Exp. duration:
8 h

Applicant's summary and conclusion

Conclusions:
In an inhalation experiment rats showed no mortalities at 8h exposure to saturated vapour at 20°C or a mist generated at 170°C. Thus tetrahydronaphthalene showed low acute toxicity in rats after inhalation.
Executive summary:

Groups of 6 rats each tolerated 8 hour exposure to substantially saturated vapour at room temperature (calculated at 1.8 mg tetrahydronaphthalene per litre air considering a vapour pressure of 34 Pa at 20°C) or to mist generated by aerating the compound while it was heated at 170°C (corresponding to 10.5 mg/L with a vapour pressur of 290 Pa at 170°C)