Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 253-575-7
CAS number: 37640-57-6
Sodium hippurate was provided an equivalent amount of sodium
administered to high-dose sodium isocyanurate animals as second control.
Weanlings from the F1 and F2 litters were randomly selected as parents
for the next generation and continued on treatment. Related litters and
F3 offsprings were sacrificed 4 weeks after weaning and organ weight
measurements and microscopic examination of tissues were carried out.
The parental animals exhibited no alteration in reproductive parameters
including the copulation index, fertility index, gestation length,
numbers of corpora lutea or implantation, implantation index, gestation
index, delivery index, and behavior at delivery and lactation. There
were no significant differences in offspring parameters including number
of offspring or live offspring, the sex ratio, live birth index,
viability index and body weight. No external or visceral abnormalities
related to the test substance were detected in any of the offspring.
Therefore, NOAEL for parental fertility and offsprings was considered to
be 600 mg/kg/day. Parental animals sufferend from adverse effects on
kidney at 600 mg/kg bw/d.
Results are not yet available.
(2,4,6-triamino-s-triazine) was administered in the diet to F344 rats or
B6C3F1 mice for 13 weeks (subchronic) to determine its toxicologic
profile. The dose levels of melamine in the subchronic studies ranged
from 750 to 18000 ppm for rats, and 6000 to 18000 ppm for mice. In these
studies, compound-related lesions were observed in the urinary tract.
Most noticeable was the development of uroliths (urinary bladder
stones), which occurred at a greater frequency in males than females of
either species. Increased incidences of urinary bladder stones and
hyperplasia of the bladder epithelium were observed at 13 weeks in male
rats fed diets containing melamine.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again