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EC number: 253-575-7
CAS number: 37640-57-6
MEL and CYA (1:1) exposure produced renal toxicity,
apparently due to significant chemical accumulation in kidney
accompanied by low excretion.
a 7 day repeated dose toxicity study (Kim et al., 2014), groups of male
rats were treated by oral gavage with a 1:1 mixture of melamine (MEL)
and cyanuric acid (CYA). Additional groups received 100 mg/kg bw/d MEL
or 100 mg/kg w/d CYA. A concurrent control group was treated with the
vehicle (aqueous CMC/Tween 80) alone. Mortality, body weight, and
clinical chemistry, urinalysis and toxicokinetic parameters were
assessed. After scheduled necropsy selected organ weights were
determined and the kidneys were examined microscopically. MEL and CYA
contents were determined in homogenized kidneys. Only the combined
exposure to MEL and CYA (1:1) induced nephrotoxicity. According to the
results of this study, combined dosing at high dose levels might produce
renal toxicity due to significant chemical accumulation in kidney
accompanied by low excretion. Based
on crystal formation in kidneys with associated nephrotoxicity and
secondary changes in investigated parameters at 20 and 100 mg/kg bw/d
MEL and CYA (1:1), a NOAEL of 4 mg/kg bw/d can be deemed for exposure to
MEL and CYA (1:1) under the conditions of this study (no NOAEL was set
by the study authors).
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