Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 253-575-7
CAS number: 37640-57-6
Melamine cyanurate was tested for skin and eye irritation in OECD guideline und GLP compiant studies in rabbits and was found to be not irritating to skin and to eyes.
Table 1: Individual eye irritation scores
Time after dosing
Fluor area (%)
First animal (#91)
Second animal (#93)
Third animal (#96)
Fluor area (%): green staining (percentage of total corneal area) after fluorescein treatment; b: Remnants of the test substance in the eye.
No indication of skin irritation was observed in rabbits (Bromine
Compound Ltd., 2000b). Draize scores for erythema and edema were 0 for
all observation time points. As the study followed OECD testing
guideline 404 and the principles of GLP, it is valid without
In the eye
irritation study in rabbits, mild transient redness of conjunctivae with
a mean Draize score of 0.3 was observed (Bromine Compound Ltd, 2000c). As
the study followed OECD testing guideline 405 and the principles of GLP,
it is valid without restrictions.
Dangerous Substance Directive (67/548/EEC)
The available studies are considered reliable and suitable for
classification purposes under 67/548/EEC. As a result the substance is
not considered to be classified for skin and eye irritation under
Directive 67/548/EEC, as amended for the 28th time in Directive
Classification, Labelling, and Packaging Regulation (EC) No. 1272/2008
The available experimental test data are reliable and suitable for
classification purposes under Regulation 1272/2008. As a result the
substance is not considered to be classified for skin or eye irritation
under Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again