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EC number: 253-575-7
CAS number: 37640-57-6
Exposure conditions: Supply air: 1.5 ± 0.0
m³/h, exhaust air: 0.6 ± 0.0 m³/h,
Test substance preparation: 62.8 g/h,
temperature: 22.8 ± 0.3 °C, relative humidity: 22.2 ±
Analytical concentration: 5.075 ± 0.622
mg/L (nominal concentration: 52.3 mg/L)
Particle size analysis: MMAD (µm) / GSD: 3.5
/ 2.6 (sample 1), 3.3 / 2.1 (sample 2)
In a GLP-compliant acute inhalation
toxicity study according to OECD 403 (single 4 -hour exposure, nose
only; limit test), male and female Wistar rats were exposed to the test
item melamincyanurat as a dust (key study, BASF 13I0834/09I058).
Mortality, clinical signs and body weights were recorded during the 14
day observation period. At necropsy, a macroscopical examination was
conducted. The actual measured test item concentration was 5.057 mg/L.
Particle size distributions were well within the respirable range, with
mass median aerodynamic diameters (MMADs) of 3.5 and 3.3 μm and
geometrical standard deviations of 2.6 and 2.1. There was no mortality.
Clinical signs of toxicity comprised of laboured respiration noted
during exposure (Hour 2 to Hour 4) and substance contaminated fur (Day
0). No clinical signs were observed from study Day 1 onwards. Mean body
weights decreased on the first post exposure observation days but
increased thereafter. No gross pathological abnormalities were detected.
The 4 -hour LC50 value was deemed as > 5.1 mg/L (calculated based on
analytical concentraton) under the conditions of this study.
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