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EC number: 253-575-7
CAS number: 37640-57-6
According to REACH Annex IX 9.4 studies investigating the effects
on terrestrial organisms do not need to be conducted if direct and
indirect exposure to the soil compartment is unlikely.
Furthermore, melamine has a low potential to absorb to soil. Based
on the low n-octanol/water partition coefficient also the adsorption to
soil or sediment is expected to be low, i.e. in the range of 1.1 to 1.5.
(EPI Suite Calculation: Koc: 32.28 L/kg; Log Koc: 1.509)
REACH criterion: "In the absence of toxicity data for soil
organisms, the equilibrium partitioning method may be applied to assess
the hazard to soil organisms." Guidance Document R.7.c.: The PNECsoil
can be estimated by the equilibrium partitioning method from the
PNECaquatic, especially in case the substance is not strongly
adsorptive, as is melamineThis method is used to estimate the PNEC.
Melamine has a low toxicity to mammals and aquatic organisms, not
leading to a classification.
The chemical safety assessment therefore does not include a risk
assessment and therefore do not indicate the need to investigate further
the effects of the substance and/or degradation products on terrestrial
Guidance Document R.7.c.: "The absence of chronic or long-term
effects in aquatic organisms up to the substance solubility limit, or of
acute effects within the solubility range above 10 mg/l (melamine
meets both criteria) can be used to waive the data requirements of
Annex IX and X."
The supporting studies, 2 on plant toxicity (Jansen 1982, Koch
1986) and 1 on soil nitrifying microorganisms (Hauck 1964) indicate a
low toxicity of melamine.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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