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EC number: 253-575-7
CAS number: 37640-57-6
In a key study (BASF SE,
50F0834/09E041, 2016), the fish early life-stage toxicity test of the
test substance using fathead minnow (Pimephales promelas) was conducted
for a period of 33 days, following the OECD 210 (2013) and the US EPA
Guidelines (OPP Subdivision E 72-4 (a) and OPPTS 850.1400. The overall
no observed effect concentration (NOEC) was >10 mg/L (nominal
concentration). The overall lowest observed effect concentration (LOEC)
was >10 mg/L (nominal concentration).
Furthermore, two valid studies conducted
with melamine itself are available (Adema, Goodrich) that did not reveal
regulatorily relevant effects.
In addition to the above mentioned studies,
several publications are available that used mixtures of melamine and
cyanuric acid to expose different fish species via the diet. Similar to
mammals crystal formation in the kidneys could be observed. However, the
exposure route via the diet is not regarded as relevant as the compounds
are not adsorptive. The effects are not regarded relevant for the hazard
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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