Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 217-168-8 | CAS number: 1761-71-3
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Low bioaccumulation potential and low risk of concentration in breast milk.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
4,4'-methylenebis(cyclohexylamine) has a low molecular weight and moderate water solubility are favourable for absorption through the GI tract. Its moderate log P value will also favor passive diffusion through the skin, especially if compromised due to caustic damage. These factors are also favorable for distribution throughout the body. The major routes of metabolism of 4,4'-methylenebis(cyclohexylamine) (and of other primary amines) include oxidation, conjugation, and other enzyme-catalyzed reactions. This results in detoxification and excretion in urine or faeces. These characteristics indicate that 4,4'-methylenebis(cyclohexylamine) has a low bioaccumulation potential and a low potential to concentrate in breast milk.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
