Registration Dossier
Registration Dossier
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EC number: 202-425-9 | CAS number: 95-50-1
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Title:
- No information
- Author:
- De Ceaurriz, J. et al.: J. Appl. Toxicology 8, 417-422|(1988)
Materials and methods
- Type of study / information:
- Type: other
- Principles of method if other than guideline:
- Whole-body exposure to o-dichlorobenzene vapours for 4 hours. Tubular toxicity and centrilobular liver demage were evaluated histochemically from the enumeration of damaged proximal tubules in cryostat kidney sections stained for alkaline phosphatase and the measurement of centrilobular glucose-6-phosphatase.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1,2-dichlorobenzene
- EC Number:
- 202-425-9
- EC Name:
- 1,2-dichlorobenzene
- Cas Number:
- 95-50-1
- Molecular formula:
- C6H4Cl2
- IUPAC Name:
- 1,2-dichlorobenzene
Constituent 1
Results and discussion
Any other information on results incl. tables
Table1. Effect of o-dichlorobenzene (DCB) (15 minutes exposure) on the respiratory rate of mice
| Respiratory rate | ||||
| Test compound | Exposure concetrationa (ppm) |
Before exposureb | During exposureb (breaths/min) |
Percentage decrease |
| DCB | (breaths/min) |
|||
| 116 | 240 ± 11.6 | 177 ± 11.3* | 26 | |
| 153 | 253 ± 5.7 | 139 ± 8.8* | 45 | |
| 196 | 266 ± 17.0 | 121 ± 17.0* | 55 | |
| 273 | 249 ± 7.2 | 81 ± 4.1* | 68 | |
a The exposure concentrations are the average of the three samples taken during each 15 min exposur period, with a coefficient of varaition of < 10%.
b The values given are the mean respiratory rate ± SEM obtained from six mice.
* Signifcantly different from pre-exposure level: p < 0.05
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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