Registration Dossier
Registration Dossier
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EC number: 201-152-2 | CAS number: 78-87-5
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Results from a GLP, OECD 429 guideline mouse local lymph node assay (Woolhiser et al., 2003) found no stimulation of lymphocyte proliferation in auricular lymph nodes from mice treated with up to 80% 1,2-dichloropropane, demonstrating that the substance is not a sensitizer under the conditions of this test. This lack of allergic potential in the mouse is consistent with structural considerations which provide no evidence of chemical alerts (reactive groups) that would indicate a potential to act as a sensitizer.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
Justification for classification or non-classification
Based on the results of testing reported 1,2-dichloropropane has not been classified as skin sensitizer.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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