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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
disregarded due to major methodological deficiencies
Study period:
1971
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Older study conducted prior to the introduction of GLP and OECD test guidelines. Standard methods used but details of methods and results not available. For read-across justification see Section 13.

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1971
Report Date:
1971

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Rats given single doses of DUP of up to at least 1.8 mg/l as a vapour. Animals observed for signs of toxicity for 10 days. Animals weighed and subject to necropsy and macroscopic examination.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
No data

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No data

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
not specified
Details on inhalation exposure:
6 h exposure at room temperature & 300 degrees F
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
6 h
Concentrations:
Up to at least 1.8 mg/l
No. of animals per sex per dose:
4
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days (or other?): 10d
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: yes/no: yes
- Other examinations performed: clinical signs, body weight, organ weights, histopathology, other: No
Statistics:
No data

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
LC50
Effect level:
> 1.8 mg/L air (nominal)
Based on:
test mat.
Exp. duration:
6 h
Remarks on result:
other: Room temperature; No 95% confidence limits calculable
Sex:
not specified
Dose descriptor:
LC50
Effect level:
> 1.8 mg/L air (nominal)
Based on:
test mat.
Exp. duration:
6 h
Remarks on result:
other: T degrees F = 300; 95% CL not calculable
Mortality:
None at room temperature or 300 degrees F
Clinical signs:
other: No toxic effects at room temperature. At 300 degrees F slight lethargy
Body weight:
None at room temperature or 300 degrees F
Gross pathology:
None at room temperature or 300 degrees F

Applicant's summary and conclusion

Interpretation of results:
relatively harmless
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
Six hours exposure to a saturated vapour concentration of 1.8 mg/L, resulted in no mortality.
Executive summary:

Six hours exposure to a saturated vapour concentration of 1.8 mg/L, resulted in no mortality. The vapour concentration tested is considered to represent the highest achievable