Registration Dossier

Administrative data

Workers - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
2 085 mg/m³
Acute/short term exposure
DNEL related information

Local effects

Acute/short term exposure
DNEL related information

Workers - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
300 mg/kg bw/day
Acute/short term exposure
DNEL related information

Workers - Hazard for the eyes

Additional information - workers

The pattern of identified uses described for isoheptane includes short-term peak exposure by inhalation and the dermal route as well as long-term repeated exposure by inhalation and the dermal route. In the case of short-term exposure, it is not possible to derive a DNEL for systemic effects, since CNS toxicity (narcotic effects) and local irritation on the skin are the leading effects.Therefore, appropriate risk management measures will be identified.

EU (2000). European Commission Directive 2000/39/EC of 8 June 2000 establishing a first list of indicative occupational exposure limit values in implementation of Council Directive 98/24/EC on the protection of the health and safety of workers from the risks related to chemical agents at work.

General Population - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
447 mg/m³
Acute/short term exposure
DNEL related information

Local effects

Acute/short term exposure
DNEL related information

General Population - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
149 mg/kg bw/day
Acute/short term exposure
DNEL related information

General Population - Hazard via oral route

Systemic effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
149 mg/kg bw/day
Acute/short term exposure
DNEL related information

General Population - Hazard for the eyes

Additional information - General Population

The pattern of identified uses described for isohheptane includes short-term peak exposure by inhalation and the dermal route as well as long-term repeated exposure by inhalation and the dermal route. In the case of short-term exposure, it is not possible to derive a DNEL for systemic effects, since CNS toxicity (narcotic effects) and local irritation on the skin are the leading effects.Therefore, appropriate risk management measures will be identified.

The assessment factors used to derive the relevant DNELs were taken from ECETOC 2003 and other, more recent, information.

References: 

ECETOC (2003). Derivation of assessment factors for human health risk assessment. Technical report No. 86, (European Centre for Ecotoxicology and Toxicology of Chemicals) Brussels.