Registration Dossier
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EC number: 250-610-8 | CAS number: 31394-54-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Additional information
There are no measured acute toxicity data available for isoheptane on fish. Data are read-across to hydrocarbons, C7-C9, isolkanes based on a category-approach. A study with the latter substance was conducted according to OECD 203 (CEFIC 1995). The acute toxicity, as measured by mortality to rainbow trout (Oncorhynchus mykiss), was evaluated in freshwater by using water accomodated fractions (WAFs). Under the conditions of this study, the test substance, hydrocarbons, C7-C9, isoalkanes produced acute lethal toxicity to Oncorhynchus mykiss at 18.4 mg/L (CEFIC 1995) based on nominal loadings of the test substance in water.
The long-term toxicity to fish was calculated using the Petrotox computer model (v. 3.04), which combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partitioning coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism. The estimated freshwater fish 28 -day NOELR value is 2.426 mg/L.
Data on the acute toxicity on freshwater and marine aquatic invertebrate species are read-across to 2,3,4-trimethylpentane (Adema & van den Bos Bakker 1987). The acute toxicity, as measured by immobilisation of Daphnia and mortality to Chaetogammarus and Mysidopsis, was evaluated in fresh- and saltwater by using water accomodated fractions (WAFs). The test substance produced acute toxicity to Daphnia and Mysidopsis at 2.4 mg/L, and to Chaetogammarus at 5.4 mg/L based on nominal loadings of the test substance in water. Data on the chronic toxicity are read-across to hydrocarbons, C7-C9, n-alkanes, isoalkanes, cyclics based on a category approach. A study of the chronic toxicity, as measured by survival, sublethal effects, reproduction, and length of first generation adults, conducted with Daphnia using WAFs (Wilbury Laboratories 2004) resulted in a NOELR of 1 mg/L.
Toxicity to algae and microorganis was estimated using the Petrotox computer model (v. 3.04). The estimated freshwater algae 72-h EL50 (Effect Loading Rate) and NOELR (No Observed Effect Loading Rate) values are 8.204 and 1.835 mg/L, respectively, based on biomass. The estimated protozoan, Tetrahymena pyriformis, 48-hr EL50 value is 42.756 mg/L based on growth inhibition.
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