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Diss Factsheets
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EC number: 931-740-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
There are no studies available from the target substance. The composition of UVCB-substance mainly consists of primary alcohols derived as a still residue obtained from the rectification of butyl alcohols by using the naphtheno-evaporating procedure in propylene oxosynthesis. The surrogate substance, 2-ethylhexanol, was used.
Rapid absorption, metabolism and excretion of 2-EH as oxidized metabolites predominantly in urine was observed following oral ingestion. Bioaccumulation is unlikely due to virtually complete excretion within 28 hrs.
Acute dermal toxicity study report exhibited that the target substance was fully absorbed, with no excessive irritation.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
There are no studies available made from the target substance. The composition of UVCB-substance mainly consists of primary alcohols derived as a still residue obtained from the rectification of butyl alcohols by using the naphtheno-evaporating procedure in propylene oxosynthesis. The surrogate substance, 2-ethylhexanol, was used. The target organs of 2-ethylhexanol in rodents are the liver, the kidney, the central nervous system and the mucosa of respiratory and gastrointestinal tracts, depending on the route of administration.
Toxicokinetics of 2-ethylhexanol was investigated by Albro, P. W. (1975). The test substance was efficiently absorbed following oral administration to rats. 14C associated with 2-ethyl[1-14C]-hexanol was rapidly excreted in respiratory CO2 (6-7%), faeces (8-9%) and urine (80-82%), with essentially complete elimination by 28 h after administration. There was no difference between the low or high dose (9 μg/kg bw and 278 mg/kg bw, resp.). The major metabolite is 2-ethylhexanoic acid, which appears in urine; alternatively it may also be further metabolized by either ß-oxidation or omega and omega-1 oxidation. Only 3% of the 2-ethylhexanol are excreted unchanged. 2-EH is a good substrate for mammalian dehydrogenases which leads to 2-ethylhexanoic acid which can be conjugated or further metabolized via partial ß-oxidation, or omega- and omega-1 oxidation, followed by conjugation (Albro, 1975). 2-EH inhibits the mitochondrial ß-oxidation of fatty acids in-vitro and in-vivo, which results in decreased levels of plasma ketones, and increased levels of hepatic total lipids and triglycerides. In contrast, the peroxisomal oxidation pathways are not inhibited by 2 -EH (Badr, 1990). Overall, 2-EH was rapidly absorbed, metabolized, and excreted mainly via urine within 28 hours following the oral administration to rats. Accumulation of 2-EH or its metabolites is unlikely to occur.
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